N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide
CAS No.:183794-51-6
Molecular Formula:C₄₇H₄₈ClN₃O₈S
Molecular Weight:850.432
Hs Code.:

N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

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Chemical Property of N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

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Technology Process of N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

There total 10 articles about N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183794-50-5
N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

: 183794-51-6
N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo961114p

Reference yield:

: 183794-28-7
{(2R,3S)-3-[(S)-2-Amino-3-(4-benzyloxy-phenyl)-propoxymethyl]-oxiranyl}-methanol

: 183794-51-6
N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / dioxane / 9 h / Heating

2: 80 percent / triethylamine / CH₂Cl₂ / 1.17 h

3: 99 percent / collidine / CH₂Cl₂ / 1.25 h

4: 79 percent / triethylamine / acetonitrile / 10 h / Heating

5: 49 percent / tetrahydrofuran / 0.5 h / 0 °C

6: Bu₄NF / tetrahydrofuran

With 2,3,5-trimethyl-pyridine; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jo961114p

Reference yield:

: 183794-29-8
(S)-1-[(3R,5S)-5-(4-Benzyloxy-benzyl)-morpholin-3-yl]-ethane-1,2-diol

: 183794-51-6
N-[(S)-1-[(3S,6R,7S)-3-(4-Benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 1.17 h

2: 99 percent / collidine / CH₂Cl₂ / 1.25 h

3: 79 percent / triethylamine / acetonitrile / 10 h / Heating

4: 49 percent / tetrahydrofuran / 0.5 h / 0 °C

5: Bu₄NF / tetrahydrofuran

With 2,3,5-trimethyl-pyridine; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo961114p