Technology Process of 4-(3-benzyloxycarbonylamino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzoic acid
There total 13 articles about 4-(3-benzyloxycarbonylamino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: CH2Cl2
2: aq. NaOH / 0 °C
3: NH3 / methanol
4: NaH / tetrahydrofuran
5: Mg; I2 / tetrahydrofuran
6: HCl / ethyl acetate
7: iAmONO; tBuOK / toluene
8: Et3N / tetrahydrofuran
9: H2 / Pd/C / methanol
10: aq. Na2CO3 / dioxane
11: HCl / dioxane
12: Et3N / CH2Cl2
13: aq. NaOH / tetrahydrofuran
With
hydrogenchloride; sodium hydroxide; potassium tert-butylate; ammonia; hydrogen; iodine; sodium hydride; sodium carbonate; magnesium; triethylamine; isopentyl nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(02)00909-5
- Guidance literature:
-
Multi-step reaction with 10 steps
1: NaH / tetrahydrofuran
2: Mg; I2 / tetrahydrofuran
3: HCl / ethyl acetate
4: iAmONO; tBuOK / toluene
5: Et3N / tetrahydrofuran
6: H2 / Pd/C / methanol
7: aq. Na2CO3 / dioxane
8: HCl / dioxane
9: Et3N / CH2Cl2
10: aq. NaOH / tetrahydrofuran
With
hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; iodine; sodium hydride; sodium carbonate; magnesium; triethylamine; isopentyl nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(02)00909-5
- Guidance literature:
-
Multi-step reaction with 12 steps
1: aq. NaOH / 0 °C
2: NH3 / methanol
3: NaH / tetrahydrofuran
4: Mg; I2 / tetrahydrofuran
5: HCl / ethyl acetate
6: iAmONO; tBuOK / toluene
7: Et3N / tetrahydrofuran
8: H2 / Pd/C / methanol
9: aq. Na2CO3 / dioxane
10: HCl / dioxane
11: Et3N / CH2Cl2
12: aq. NaOH / tetrahydrofuran
With
hydrogenchloride; sodium hydroxide; potassium tert-butylate; ammonia; hydrogen; iodine; sodium hydride; sodium carbonate; magnesium; triethylamine; isopentyl nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0960-894X(02)00909-5
