1133-42-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-3,4-Dihydro-1H-1,4-Benzodiazepine-2,5-Dione is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its specific use in this industry is determined by its bioactivity and the modification of properties due to the additional functional groups.
Used in Organic Chemistry Research:
1-Methyl-3,4-Dihydro-1H-1,4-Benzodiazepine-2,5-Dione is used as a research compound in organic chemistry. Its unique structure and potential modifications due to the functional groups make it a subject of interest for studying its properties and potential applications in various chemical reactions and synthesis processes.
Note: Since there is limited information available about the detailed characteristics and applications of 1-Methyl-3,4-Dihydro-1H-1,4-Benzodiazepine-2,5-Dione, the uses mentioned above are based on the general properties of Benzodiazepines and the potential modifications due to the additional functional groups. Further biochemical and pharmacological studies would be required to determine the specific uses and hazards of this particular derivative.

InChI:InChI=1/C10H10N2O2/c1-12-8-5-3-2-4-7(8)10(14)11-6-9(12)13/h2-5H,6H2,1H3,(H,11,14)

Upstream product

• 10328-92-4 N-Methylisatoic anhydride 
• 56-40-6 glycine 
• 65-85-0 benzoic acid 
• 141871-02-5 N-Boc-methyl anthranilic acid 
• 85-91-6 Methyl N-methylanthranilate 
• 5946-42-9 methyl 2-(N-bromoacetyl-N-methylamino)benzoate 
• 159878-80-5 Boc Me Ant-Gly-OMe 
• 57247-55-9 2-(methylamino)hippuric acid ethyl ester 
• 2185-00-4 1,3-oxazolidine-2,5-dione 

Downstream Products

• 155849-43-7 1,2-Dihydro-5-(4-methoxypiperidin-1-yl)-3H-1-methyl-1,4-benzodiazepin-2-one 
• 154967-59-6 (-)-N-[5-(3-azabicyclo[3.2.2]nonan-3-yl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'-[3-methylphenyl]urea 

Relevant academic research and scientific papers

Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase

This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

A new series of potent benzodiazepine gamma-secretase inhibitors.

A new series of benzodiazepine-containing gamma-secretase inhibitors with potential use in the treatment of Alzheimer's disease is disclosed. Structure-activity relationships of the pendant hydrocinnamate side-chain which led to the preparation of highly

Benzodiazepine derivatives

Compounds of Formula (I), and salts and prodrugs thereof, wherein R1 represents H, optionally substituted C1-6 alkyl or C3-7 cycloalkyl; R2 is NHR12 or (CH2)s R13 where 5 is 0, 1 or 2; R3 represents C1-6 alkyl, halo or NR6 R7 ; R4 and R5 are H, C1-12 alkyl optionally substituted by NR9 R9' or an azacyclic or azabicyclic group, optionally substituted C4-9 cycloalkyl, C4-9 cycloalkyl C1-4 alkyl, aryl, arylC1-6 alkyl or azacyclic or azabicyclic groups, or R4 and R5 together form the residue of an optionally substituted azacyclic or azabicyclic ring system; x is 0, 1, 2 or 3; R12 is optionally substituted phenyl or pyridyl; R13 represents a group (A) wherein R14 is H or C1-6 alkyl; R15 is H, C1-6 alkyl, halo or NR6 R7 ; and the dotted line is an optional covalent bond; are CCK and/or gastrin antagonists useful in therapy. STR1

New routes to 1,4-benzodiazepin-2,5-diones

1,4-benzodiazepin-2,5-diones have been synthesized in good overall yields by two routes, the first one by cyclisation of dipeptides prepared from Boc anthranilic acid and α-amino acid methyl esters, the second one by reaction of N-carboxy α-amino acid anhydrides with Boc anthranilic acid.

New synthesis of 1,4 benzodiazepine-2,5-diones by means of HCl gas catalyst

A new synthesis of 1,4-benzodiazepinediones 4, particularly 1,4-dihydro1H-1,4-benzodiazepine-2,5-dione, 4c key intermediate of metabolites cyclopenin 9, cyclopenol 10, cyclopeptine 11 and dehydrocyclopeptide 12, was achieved by action of dry HCl gas in DM

A Versatile Synthesis of 3H-1(H),4(H)-Benzodiazepin-2,5-diones

Reaction of isatoic anhydrides (1) and α-amino acids (2) in glacial acetic acid under reflux gave 3H-1(H),4(H)-benzodiazepin-2,5-diones (3) in good yields.These compounds have been characterised by UV, IR, mass, PMR and 13C-NMR spectra.