(4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Base Information

Chemical Name:(4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
CAS No.:1624603-59-3
Molecular Formula:C₂₅H₂₀F₅N₅O
Molecular Weight:501.459
Hs Code.:

(4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

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Chemical Property of (4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

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Technology Process of (4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

There total 15 articles about (4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1624603-21-9
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-1,7-naphthyridin-8-amine

: 1624603-59-3
(4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:

Reference yield:

: 930303-55-2
2-chloro-1,7-naphthyridin-8(7H)-one

: 1624603-59-3
(4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate

2: sulfuric acid / ethyl acetate

With sulfuric acid; In ethyl acetate; trichlorophosphate;

Reference yield:

: 1600511-51-0
1-(5-bromo-2-fluorophenyl)-2-fluoroethan-1-one

: 1624603-59-3
(4S,6S)-4-(5-((3-(cyclopropylethynyl)-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 11 steps

1: tetrahydrofuran; ethyl acetate; water

2: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

3: sodium borohydrid; ammonia / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

5: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

6: hydrogenchloride / ethyl acetate; 1,4-dioxane

7: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

8: ammonium chloride; nitrogen; ammonium hydroxide / water; ethanol

9: ethyl acetate

10: sulfuric acid / ethyl acetate

With hydrogenchloride; ammonium hydroxide; n-butyllithium; sodium borohydrid; triethanolamine; sulfuric acid; nitrogen; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethanol; acetic acid methyl ester; water; ethyl acetate; acetonitrile;