2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

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Chemical Name:2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester
CAS No.:91741-74-1
Molecular Formula:C₄₀H₄₇F₅N₈O₈S₂
Molecular Weight:926.986
Hs Code.:

2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

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Chemical Property of 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

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Technology Process of 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

There total 84 articles about 2-[({2-[(R)-1-((S)-2-{(S)-2-[((S)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21461-84-7
(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

: 91741-74-1
2-[({2-[(R)-1-((R)-2-{(R)-2-[((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 94 percent / SOCl₂

2: 91 percent / NH₃

3: 80 percent / Lawessons reagent

4: 52 percent

5: 82 percent / NH₃

6: 78 percent / (CF₃CO)2O / pyridine

7: 90 percent / HN₃, azodicarbonic ethylester, Ph₃P

8: 80 percent / H₂ / Pd

9: 97 percent

10: 1) CF₃COOH; 2) (PhO)2PON₃

11: 95 percent / NaOH / H₂O

12: 70 percent / (PhO)2PON₃

13: 1) NaOH / 1) H₂O; 2) pyridine

With Lawessons reagent; sodium hydroxide; thionyl chloride; tris-(2-chloro-ethyl)-amine; azodicarbonic ethylester; diphenyl phosphoryl azide; ammonia; hydrogen; triphenylphosphine; trifluoroacetic acid; trifluoroacetic anhydride; palladium; In pyridine; water;

Reference yield:

: 54848-33-8
(S)-tetrahydro-5-oxo-2-furancarbonyl chloride

: 91741-74-1
2-[({2-[(R)-1-((R)-2-{(R)-2-[((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 91 percent / NH₃

2: 80 percent / Lawessons reagent

3: 52 percent

4: 82 percent / NH₃

5: 78 percent / (CF₃CO)2O / pyridine

6: 90 percent / HN₃, azodicarbonic ethylester, Ph₃P

7: 80 percent / H₂ / Pd

8: 97 percent

9: 1) CF₃COOH; 2) (PhO)2PON₃

10: 95 percent / NaOH / H₂O

11: 70 percent / (PhO)2PON₃

12: 1) NaOH / 1) H₂O; 2) pyridine

With Lawessons reagent; sodium hydroxide; tris-(2-chloro-ethyl)-amine; azodicarbonic ethylester; diphenyl phosphoryl azide; ammonia; hydrogen; triphenylphosphine; trifluoroacetic acid; trifluoroacetic anhydride; palladium; In pyridine; water;

Reference yield:

: 91711-86-3
2-((S)-5-Oxo-tetrahydro-furan-2-yl)-thiazole-4-carboxylic acid ethyl ester

: 91741-74-1
2-[({2-[(R)-1-((R)-2-{(R)-2-[((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-3-cyano-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / NH₃

2: 78 percent / (CF₃CO)2O / pyridine

3: 90 percent / HN₃, azodicarbonic ethylester, Ph₃P

4: 80 percent / H₂ / Pd

5: 97 percent

6: 1) CF₃COOH; 2) (PhO)2PON₃

7: 95 percent / NaOH / H₂O

8: 70 percent / (PhO)2PON₃

9: 1) NaOH / 1) H₂O; 2) pyridine

With sodium hydroxide; tris-(2-chloro-ethyl)-amine; azodicarbonic ethylester; diphenyl phosphoryl azide; ammonia; hydrogen; triphenylphosphine; trifluoroacetic acid; trifluoroacetic anhydride; palladium; In pyridine; water;