2,5-bis(4-tert-butylphenyl)-3-cyanofuran

Base Information

• Chemical Name: 2,5-bis(4-tert-butylphenyl)-3-cyanofuran
• CAS No.: 103982-22-5
• Molecular Formula: C₂₅H₂₇NO
• Molecular Weight: 357.495
• Mol file: 103982-22-5.mol

Synonyms:

Chemical Property of 2,5-bis(4-tert-butylphenyl)-3-cyanofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-bis(4-tert-butylphenyl)-3-cyanofuran

There total 5 articles about 2,5-bis(4-tert-butylphenyl)-3-cyanofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

copper(I) cyanide (544-92-3) + 3,4-dibromo-2,5-bis(4-tert-butylphenyl)furan (103982-17-8) → 2,5-bis(4-tert-butylphenyl)-3-cyanofuran (103982-22-5) + 2,5-bis(4-tert-butylphenyl)-3,4-dicyanofuran (103982-18-9)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; for 5h; Heating;

DOI:10.1021/jo00372a013

Reference yield:

tert-butylbenzene (253185-03-4,253185-04-5) → 2,5-bis(4-tert-butylphenyl)-3-cyanofuran (103982-22-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 52.8 percent / AlCl₃ / various solvent(s) / 2.5 h / Ambient temperature

2: 92.3 percent / SnCl₂*2H₂O, AcOH, conc. HCl / 0.08 h / 50 °C

3: BF₃*OEt₂ / 42 h / Ambient temperature

4: 91.5 percent / Br₂ / CHCl₃ / 0.25 h / 0 °C

5: 1-methyl-2-pyrrolidinone / 5 h / Heating

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; aluminium trichloride; boron trifluoride diethyl etherate; bromine; acetic acid; tin(ll) chloride; In chloroform;

DOI:10.1021/jo00372a013

Reference yield:

(E)-1,4-bis(4-(tert-butyl)phenyl)but-2-ene-1,4-dione (103982-14-5) → 2,5-bis(4-tert-butylphenyl)-3-cyanofuran (103982-22-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 92.3 percent / SnCl₂*2H₂O, AcOH, conc. HCl / 0.08 h / 50 °C

2: BF₃*OEt₂ / 42 h / Ambient temperature

3: 91.5 percent / Br₂ / CHCl₃ / 0.25 h / 0 °C

4: 1-methyl-2-pyrrolidinone / 5 h / Heating

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; boron trifluoride diethyl etherate; bromine; acetic acid; tin(ll) chloride; In chloroform;

DOI:10.1021/jo00372a013

upstream raw materials:

copper(I) cyanide

3,4-dibromo-2,5-bis(4-tert-butylphenyl)furan

tert-butylbenzene

(E)-1,4-bis(4-(tert-butyl)phenyl)but-2-ene-1,4-dione