(S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide

Base Information

Chemical Name:(S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide
CAS No.:1010800-00-6
Molecular Formula:C₄₁H₂₅F₃NO₅PS
Molecular Weight:731.688
Hs Code.:

Synonyms:

Suppliers and Price of (S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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General Description (S)-[3,3’-di(1-naphthyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide is a chiral BINOL-based N-triflylphosphoramide, recognized as a highly acidic, metal-free Bronsted acid catalyst. Its strong acidity and structural rigidity, derived from the binaphthyl backbone and triflyl group, make it effective for asymmetric catalysis, particularly in reactions requiring robust chiral acid promoters. (S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide’s design leverages the steric and electronic properties of the naphthyl substituents to enhance enantioselectivity and reactivity.

Technology Process of (S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide

There total 3 articles about (S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 851615-07-1,863659-88-5
(S)-[2,2':4',1'':3'',2'''-quaternaphthalene]-2'',3'-diol

: 28048-16-0
(N-trichlorophosphoranylidene)trifluoromethanesulfonamide

: 1010800-00-6
(S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide

Guidance literature:: (S)-[2,2':4',1'':3'',2'''-quaternaphthalene]-2'',3'-diol; (N-trichlorophosphoranylidene)trifluoromethanesulfonamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

With water; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1055/s-0036-1588782

Reference yield:

: 421-85-2
Trifluoromethanesulfonamide

: 851615-07-1,863659-88-5
(S)-[2,2':4',1'':3'',2'''-quaternaphthalene]-2'',3'-diol

: 1010800-00-6
(S)-[3,3’-di(1-naphtyl)-1,1’-binaphthalen-2,2’-yl]-N-triflyl phosphoramide

Guidance literature:: (S)-[2,2':4',1'':3'',2'''-quaternaphthalene]-2'',3'-diol; With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

With trichlorophosphate; In dichloromethane; at 20 ℃; for 1.083h;

Trifluoromethanesulfonamide; In dichloromethane; acetonitrile; for 12h; Reflux;
DOI:10.1002/cjoc.201900544