Technology Process of 2-C-azidomethyl-5-O-benzhydryl-2,3-O-isopropylidene-D-lyxono-1,4-lactone
There total 7 articles about 2-C-azidomethyl-5-O-benzhydryl-2,3-O-isopropylidene-D-lyxono-1,4-lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
DOI:10.1021/jo4005487
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / 1 h / Reflux
2: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -78 °C
3: potassium carbonate / water; methanol / 4 h / Reflux
4: iodine; potassium carbonate / tert-butyl alcohol / 1 h / Reflux
5: pyridine / dichloromethane / 1 h / -30 - -10 °C
6: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C
With
pyridine; sodium azide; iodine; diisobutylaluminium hydride; potassium carbonate;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1021/jo4005487
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diisobutylaluminium hydride / toluene; dichloromethane / 1 h / -78 °C
2: potassium carbonate / water; methanol / 4 h / Reflux
3: iodine; potassium carbonate / tert-butyl alcohol / 1 h / Reflux
4: pyridine / dichloromethane / 1 h / -30 - -10 °C
5: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C
With
pyridine; sodium azide; iodine; diisobutylaluminium hydride; potassium carbonate;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1021/jo4005487
