2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

Base Information

Chemical Name:2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol
CAS No.:1442089-87-3
Molecular Formula:C₃₄H₄₇N₃O₇SSi
Molecular Weight:669.915
Hs Code.:

Synonyms:2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

Suppliers and Price of 2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

There total 12 articles about 2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1442089-85-1
2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-Dlyxitol

: 124-63-0
methanesulfonyl chloride

: 1442089-87-3
2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Reagent/catalyst;
DOI:10.1021/jo4005487

Reference yield:

: 100-39-0
benzyl bromide

: 1442089-87-3
2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4.5 h / -5 - 0 °C / Molecular sieve

2: sodium tetrahydroborate / ethanol / 3 h / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C / Molecular sieve

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium hydride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4005487

Reference yield:

: C₂₃H₂₃F₃O₈S

: 1442089-87-3
2-C-azidomethyl-2,3,5-tri-O-benzyl-1-O-tert-butyldimethylsilyl-4-O-methanesulfonyl-D-lyxitol

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

2: acetyl chloride / methanol / 18 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4.5 h / -5 - 0 °C / Molecular sieve

4: sodium tetrahydroborate / ethanol / 3 h / 20 °C

5: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C / Molecular sieve

6: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium azide; sodium hydride; triethylamine; acetyl chloride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4005487