(S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester
CAS No.:181622-90-2
Molecular Formula:C₃₇H₄₄N₈O₉
Molecular Weight:744.805
Hs Code.:

(S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester

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Technology Process of (S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester

There total 5 articles about (S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 181622-90-2
(S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether

2: H₂ / 10percent Pd/C / methanol / 15 h / Ambient temperature

3: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 2 h / Ambient temperature

4: HCl / ethyl acetate; CH₂Cl₂ / 0.17 h / Ambient temperature

5: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; diethyl cyanophosphonate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.1498

Reference yield:

: 59279-58-2
N^α-tert-butyloxycarbonyl-γ-benzyloxycarbonyl-L-glutamic acid methyl ester

: 181622-90-2
(S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / methanol / 15 h / Ambient temperature

2: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 2 h / Ambient temperature

3: HCl / ethyl acetate; CH₂Cl₂ / 0.17 h / Ambient temperature

4: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; diethyl cyanophosphonate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.1498

Reference yield:

: 72086-72-7
N-tert-butoxycarbonylglutamic acid methyl ester

: 181622-90-2
(S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 2 h / Ambient temperature

2: HCl / ethyl acetate; CH₂Cl₂ / 0.17 h / Ambient temperature

3: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; diethyl cyanophosphonate; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.1498