1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate>

Base Information

• Chemical Name: 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate>
• CAS No.: 136136-29-3
• Molecular Formula: C₆H₁₅N*C₄₅H₅₁ClN₄O₁₁P
• Molecular Weight: 991.539
• Mol file: 136136-29-3.mol

Synonyms:

Chemical Property of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate>

There total 5 articles about 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione (136136-27-1) + 2-chlorophenyl dichlorophosphate (15074-54-1) → 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate> (136136-29-3)

Guidance literature:

With 1,2,4-Triazole; triethylamine; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1080/00397919108019790

Reference yield:

2'-deoxyuridine (951-78-0,63844-76-8) → 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate> (136136-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 26 percent / 1 N H₂SO₄ (pH 5) / H₂O / 10 h / 100 °C

2: 71 percent / pyridine / 6 h / Ambient temperature

3: 1) 1,2,4-triazole / 1) THF, 30 min, 2) 1.5 h, rt

With pyridine; 1,2,4-Triazole; sulfuric acid; In water;

DOI:10.1002/hlca.19910740407

Reference yield:

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl (14691-88-4,78774-22-8) → 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione 3'<(2-chlorophenyl) triethylammonium phosphate> (136136-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 26 percent / 1 N H₂SO₄ (pH 5) / H₂O / 10 h / 100 °C

2: 71 percent / pyridine / 6 h / Ambient temperature

3: 1) 1,2,4-triazole / 1) THF, 30 min, 2) 1.5 h, rt

With pyridine; 1,2,4-Triazole; sulfuric acid; In water;

DOI:10.1002/hlca.19910740407

upstream raw materials:

1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-5-<<2,2,6,6-tetramethyl-1-(oxyl)piperidin-4-yl>amino>pyrimidine-2,4(1H,3H)-dione

triethylamine

2-chlorophenyl dichlorophosphate

2'-deoxyuridine