3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one

Base Information

Chemical Name:3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one
CAS No.:1482522-98-4
Molecular Formula:C₂₁H₁₈N₂O₃
Molecular Weight:346.386
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one

Chemical Property:

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Technology Process of 3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one

There total 6 articles about 3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.8%

: 1482523-76-1
3-chloro-8-methoxydibenzo[b,e]oxepin-11(6H)-one

: 95-54-5
1,2-diamino-benzene

: 1482522-98-4
3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one

Guidance literature:: With palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane; tert-butyl alcohol; at 110 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm401276h

Reference yield:

: 35598-05-1
methyl 4-methoxy-2-methylbenzoate

: 1482522-98-4
3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 72 °C

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: potassium hydroxide / water; methanol / 4 h / 40 °C

4.1: trifluoroacetic anhydride; thionyl chloride / dichloromethane / 0.5 h / 20 °C

4.2: 1.5 h

5.1: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane; tert-butyl alcohol / 3 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); palladium diacetate; potassium carbonate; caesium carbonate; trifluoroacetic anhydride; potassium hydroxide; XPhos; In 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jm401276h

Reference yield:

: 6245-57-4
4-methoxy-2-methylbenzoic acid

: 1482522-98-4
3-[(2-aminophenyl)amino]-8-methoxydibenzo[b,e]oxepin-11(6H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / water / 6 h / Reflux

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 72 °C

3.1: potassium carbonate / acetone / 4 h / Reflux

4.1: potassium hydroxide / water; methanol / 4 h / 40 °C

5.1: trifluoroacetic anhydride; thionyl chloride / dichloromethane / 0.5 h / 20 °C

5.2: 1.5 h

6.1: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane; tert-butyl alcohol / 3 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; palladium diacetate; potassium carbonate; caesium carbonate; trifluoroacetic anhydride; potassium hydroxide; XPhos; In 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jm401276h