N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin

Base Information

• Chemical Name: N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin
• CAS No.: 171777-71-2
• Molecular Formula: C₂₅H₂₉N₇O₇
• Molecular Weight: 543.516
• Mol file: 171777-71-2.mol

Synonyms:

Chemical Property of N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin

There total 8 articles about N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester-azomethin>-pterin (171777-70-1) → N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin (171777-71-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 45 ℃;

DOI:10.1002/jlcr.2580361010

Reference yield:

(2)H8-toluene (2037-26-5) → N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin (171777-71-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) HNO₃, <2H₂>sulfuric acid, 2.) sodium dichromate, H₂SO₄ / 1.) D₂O, 1.5 h, 2.) H₂O, reflux, 5 h

2: 2.43 g / PCl₅ / 0.25 h / 60 °C

3: 2.39 g / triethylamine / benzene / 0.25 h / Ambient temperature

4: 0.862 g / H₂ / 10percent Pd/C / ethanol / 1 h

5: 262 mg / 0.25 h / 120 - 125 °C / 0.01 Torr

6: 118 mg / sodium borohydride / ethanol / 45 °C

With sodium tetrahydroborate; sodium dichromate; phosphorus pentachloride; sulfuric acid; hydrogen; nitric acid; sulfuric acid-d2; triethylamine; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1002/jlcr.2580361010

Reference yield:

4-nitro<2,3,5,6-2H4>benzoic acid (171777-66-5) → N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester>-pterin (171777-71-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.43 g / PCl₅ / 0.25 h / 60 °C

2: 2.39 g / triethylamine / benzene / 0.25 h / Ambient temperature

3: 0.862 g / H₂ / 10percent Pd/C / ethanol / 1 h

4: 262 mg / 0.25 h / 120 - 125 °C / 0.01 Torr

5: 118 mg / sodium borohydride / ethanol / 45 °C

With sodium tetrahydroborate; phosphorus pentachloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1002/jlcr.2580361010

upstream raw materials:

N(2')-acetyl-6-benzoyl)-L-glutamic acid diethyl ester-azomethin>-pterin

⁽²⁾H₈-toluene

4-nitro<2,3,5,6-2H4>benzoic acid

4-nitro<2,3,5,6-2H4>benzoyl chloride

Downstream raw materials:

<2',3',5',6'-2H4>folic acid