benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide

Base Information

• Chemical Name: benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide
• CAS No.: 121534-61-0
• Molecular Formula: C₄₃H₃₆N₂O₇S₂
• Molecular Weight: 756.9
• Mol file: 121534-61-0.mol

Synonyms:

Chemical Property of benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide

There total 10 articles about benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.9%

benzhydryl 7-(2-thienyl)acetamido-2-methylene-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide (66094-91-5) + diazodiphenylmethane (908093-98-1) → benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide (121534-61-0,121651-30-7) + benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide (121534-61-0,121651-30-7)

Guidance literature:

In dichloromethane; at 30 ℃; for 1.5h;

Reference yield: 46.9%

benzhydryl 7-(2-thienyl)acetamido-2-methylene-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide (66094-91-5) + diazodiphenylmethane (908093-98-1) → benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide (121534-61-0,121651-30-7) + benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide (121534-61-0,121651-30-7)

Guidance literature:

In dichloromethane; at 30 ℃; for 1.5h;

Reference yield:

(6R)-3-acetoxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (35607-83-1) → benzhydryl 7-(2-thienyl)acetamido-2-spirocyclopropyl-2',2'diphenyl-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide (121534-61-0,121651-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.4 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h

2: 57.16 percent / diethylamine hydrochloride / H₂O; 2-methyl-propan-2-ol / 24 h / Heating

3: 16.8 percent / CH₂Cl₂ / 1.5 h / 30 °C

With diethyl amine hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; tert-butyl alcohol;

upstream raw materials:

benzhydryl 7-(2-thienyl)acetamido-2-methylene-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide

diazodiphenylmethane

(6R)-3-acetoxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

benzhydryl 7-(2-thienyl)acetamido-3-acetoxymethyl-3-cephem-4-carboxylate 1S(β)-oxide