Technology Process of 3-(difluoromethyl)-1,2,3,5,6,7-hexahydro-s-indacen-4-amine
There total 7 articles about 3-(difluoromethyl)-1,2,3,5,6,7-hexahydro-s-indacen-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
10 wt% Pd(OH)2 on carbon; hydrogen;
In
ethanol;
at 20 ℃;
for 7h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: aluminum (III) chloride / dichloromethane / 8 h / 0 - 10 °C / Large scale
2.1: sulfuric acid / 48 h / 55 °C
2.2: 2 h / 0 - 10 °C
3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 - 20 °C
3.2: 20 °C
4.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C
5.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 0 °C
6.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 7 h / 20 °C
With
aluminum (III) chloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; 10 wt% Pd(OH)2 on carbon; hydrogen; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 48 h / 55 °C
1.2: 2 h / 0 - 10 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 - 20 °C
2.2: 20 °C
3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C
4.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 0 °C
5.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 7 h / 20 °C
With
n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; 10 wt% Pd(OH)2 on carbon; hydrogen; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; hexane; dichloromethane;