39105-39-0

Basic information

• Product Name: 3-CHLORO-1-INDAN-5-YL-PROPAN-1-ONE
• Synonyms: 3-CHLORO-1-INDAN-5-YL-PROPAN-1-ONE;5-(3-CHLOROPROPIONYL)INDAN;3-Chloro-1-(2,3-dihydro-1H-inden-5-yl)-1-propanone;5-(β-Chloropropionyl)indan;3-Chloro-1-(2,3-dihydro-1H-inden-5-yl)propan-1-one
• CAS NO: 39105-39-0
• Molecular Formula: C₁₂H₁₃ClO
• Molecular Weight: 208.68402
• Product Categories: Aromatics Compounds;Aromatics;Intermediates;Aromatics, Intermediates
• Mol File: 39105-39-0.mol
• Article Data: 24

Chemical Properties

• Melting Point: 62-65°C
• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 3-CHLORO-1-INDAN-5-YL-PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1-INDAN-5-YL-PROPAN-1-ONE(39105-39-0)
• EPA Substance Registry System: 3-CHLORO-1-INDAN-5-YL-PROPAN-1-ONE(39105-39-0)

Safety Data

• Hazardous Substances Data: 39105-39-0(Hazardous Substances Data)

Usage

Chemical Properties

3-CHLORO-1-INDAN-5-YL-PROPAN-1-ONE is Off-White Solid

Uses

Different sources of media describe the Uses of 39105-39-0 differently. You can refer to the following data:
1. 3-CHLORO-1-INDAN-5-YL-PROPAN-1-ONE is a useful synthetic intermediate
2. A useful synthetic intermediate.

Upstream product

• 496-11-7 INDANE 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 2676862-01-2 3-(difluoromethyl)-1,2,3,5,6,7-hexahydro-s-indacen-4-amine 
• 2676861-99-5 8-nitro-1,2,3,5,6,7-hexahydro-s-indacene-1-carbaldehyde 
• 2676865-19-1 2-(methoxymethyl)-4-nitro-1,2,3,5,6,7-hexahydro-s-indacene 
• 2676865-18-0 (4-nitro-1,2,3,5,6,7-hexahydro-s-indacen-2-yl)methanol 
• 2676865-17-9 ethyl 4-nitro-1,2,3,5,6,7-hexahydro-s-indacene-2-carboxylate 
• 2676864-15-4 3-(((tert-butyldimethylsilyl)oxy)methyl)-1,2,3,5,6,7-hexahydro-s-indacen-4-amine 
• 2676864-14-3 (8-amino-1,2,3,5,6,7-hexahydro-s-indacen-1-yl)methanol 
• 2676863-31-1 8-nitro-3,5,6,7-tetrahydro-2H-spiro[s-indacene-1,1’-cyclopropane] 
• 2676863-23-1 racemic 3-(trifluoromethyl)-3-((trimethylsilyl)oxy)-1,2,3,5,6,7-hexahydro-s-indacen-4-amine 
• 2676863-22-0 racemic 8-amino-1-(trifluoromethyl)-1,2,3,5,6,7-hexahydro-s-indacen-1-ol 
• 2676863-21-9 racemic 8-nitro-1-(trifluoromethyl)-1,2,3,5,6,7-hexahydro-s-indacen-1-ol 
• 2271392-87-9 (R)-3-methyl-1,2,3,5,6,7-hexahydro-s-indacen-4-amine 
• 2271392-87-9 (S)-3-methyl-1,2,3,5,6,7-hexahydro-s-indacen-4-amine 
• 2271392-87-9 3-methyl-1,2,3,5,6,7-hexahydro-s-indacen-4-amine 

Relevant articles and documents

SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS

Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

NOVEL PROCESSES

The present invention relates to processes of preparing N- ((1,2,3,4,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H- pyrazole-3-sulfonamide and salts thereof. The present invention further relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

NLRP3 INHIBITORS

The present application relates to compounds with NLRP3inhibitory activity and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present application further relates to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3inhibition.