N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide

Base Information

Chemical Name:N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide
CAS No.:109685-63-4
Molecular Formula:C₁₃H₁₆F₃NO₂
Molecular Weight:275.271
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide

There total 12 articles about N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102854-63-7
4-trifluoromethyl-2-(5H)-furanone

: 109685-63-4
N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide

Guidance literature:: Multi-step reaction with 13 steps

1: 88 percent / H₂ / 5percent Pd-C / methanol

2: toluene / 6 h / Heating

3: Et₃N / CH₂Cl₂ / 0 °C

4: NaH / tetrahydrofuran / Ambient temperature

5: c-HCl / acetic acid / 13 h / Heating

6: AcCl

7: DIBAL-H / diethyl ether / 0 °C

8: DMSO, ClCOCOCl, Et₃N / CH₂Cl₂

9: NH₄Cl, NH₄OH / ethanol

10: c-HCl / 50 - 60 °C

11: Raney-Ni(W-2) / H₂O / 90 °C

12: NaBH₄, BF₃*Et₂O / tetrahydrofuran

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; oxalyl dichloride; Raney-Ni(W-2); boron trifluoride diethyl etherate; hydrogen; sodium hydride; diisobutylaluminium hydride; ammonium chloride; dimethyl sulfoxide; triethylamine; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)85148-5

Reference yield:

: 109685-49-6
(R)-4,4,4-Trifluoro-3-phenylsulfanylmethyl-butyraldehyde

: 109685-63-4
N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄Cl, NH₄OH / ethanol

2: c-HCl / 50 - 60 °C

3: Raney-Ni(W-2) / H₂O / 90 °C

4: NaBH₄, BF₃*Et₂O / tetrahydrofuran

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; Raney-Ni(W-2); boron trifluoride diethyl etherate; ammonium chloride; In tetrahydrofuran; ethanol; water;
DOI:10.1016/S0040-4039(00)85148-5

Reference yield:

: 110847-11-5
3-trifluoromethyl-γ-butyrolactone

: 109685-63-4
N-((1R,3R)-4,4,4-Trifluoro-1-hydroxymethyl-3-methyl-butyl)-benzamide

Guidance literature:: Multi-step reaction with 12 steps

1: toluene / 6 h / Heating

2: Et₃N / CH₂Cl₂ / 0 °C

3: NaH / tetrahydrofuran / Ambient temperature

4: c-HCl / acetic acid / 13 h / Heating

5: AcCl

6: DIBAL-H / diethyl ether / 0 °C

7: DMSO, ClCOCOCl, Et₃N / CH₂Cl₂

8: NH₄Cl, NH₄OH / ethanol

9: c-HCl / 50 - 60 °C

10: Raney-Ni(W-2) / H₂O / 90 °C

11: NaBH₄, BF₃*Et₂O / tetrahydrofuran

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; oxalyl dichloride; Raney-Ni(W-2); boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; ammonium chloride; dimethyl sulfoxide; triethylamine; acetyl chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)85148-5