N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

Base Information

Chemical Name:N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide
CAS No.:169765-81-5
Molecular Formula:C₄₁H₄₆N₈O₆
Molecular Weight:746.866
Hs Code.:

N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

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Chemical Property of N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

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Technology Process of N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

There total 6 articles about N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5036-48-6
3-(1H-imidazol-1-yl)propan-1-amine

: 169765-81-5
N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1: various solvent(s) / 125 °C

2: pyridine, TEA

3: pyridine, TEA

4: Bu₄NF / tetrahydrofuran

5: pyridine, TEA

With pyridine; TEA; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)76514-2

Reference yield:

: 4291-63-8
2-chloro-2'-deoxyadenosine

: 169765-81-5
N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1: various solvent(s) / 125 °C

2: pyridine, TEA

3: pyridine, TEA

4: Bu₄NF / tetrahydrofuran

5: pyridine, TEA

With pyridine; TEA; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)76514-2

Reference yield:

: 136834-45-2
(2R,3S,5R)-5-[6-Amino-2-(3-imidazol-1-yl-propylamino)-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-ol

: 169765-81-5
N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine, TEA

2: pyridine, TEA

3: Bu₄NF / tetrahydrofuran

4: pyridine, TEA

With pyridine; TEA; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)76514-2