(R)-2-allylpiperidine hydrochloride

Base Information

• Chemical Name: (R)-2-allylpiperidine hydrochloride
• CAS No.: 139163-21-6
• Molecular Formula: C₈H₁₅N*ClH
• Molecular Weight: 161.675
• Mol file: 139163-21-6.mol

Synonyms:

Chemical Property of (R)-2-allylpiperidine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-allylpiperidine hydrochloride

There total 6 articles about (R)-2-allylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2R,RS)-2-allyl-(N-tert-butylsulfinyl)piperidine (1351810-75-7) → (R)-2-allylpiperidine hydrochloride (139163-21-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 - 23 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo202211u

Reference yield: 78.0%

5-Aminopentanal Diethyl Acetal (21938-23-8) + allyl-trimethyl-silane (762-72-1) → 2-allylpiperidine hydrochloride (33078-45-4,139163-21-6)

Guidance literature:

Multistep reaction.;

DOI:10.1002/1099-0690(200209)2002:18<3133::AID-EJOC3133>3.0.CO;2-H

Reference yield:

C8H14NPol → (S)-2-allylpiperidine hydrochloride (139163-21-6) + (R)-2-allylpiperidine hydrochloride (139163-21-6)

Guidance literature:

With hydrogenchloride; In chloroform; at 0 - 20 ℃; for 2h; merrifield resin

DOI:10.2174/1386207320666170602085724

upstream raw materials:

5-Aminopentanal Diethyl Acetal

allyl-trimethyl-silane

5,5-diethoxy-valeronitrile

(2R,RS)-2-allyl-(N-tert-butylsulfinyl)piperidine

Downstream raw materials:

(S)-1-benzyloxycarbonyl-2-(2-propenyl)piperidine

(+)-coniceine

(R)-1-benzyloxycarbonyl-2-(2-propenyl)piperidine