2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide

Base Information

Chemical Name:2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide
CAS No.:380615-24-7
Molecular Formula:C₄₄H₄₉N₅O₁₂
Molecular Weight:839.899
Hs Code.:

2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-<i>N</i>-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-<i>N</i>-methoxy-acetamide

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Chemical Property of 2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide

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Technology Process of 2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide

There total 11 articles about 2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128119-39-1
[(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetaldehyde

: 380615-24-7
2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: NaClO₂; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

2: 87 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N,N-dimethylaminopyridine / H₂O

3: Bu₄NF; pyridine / tetrahydrofuran; H₂O

4: TEA / CH₂Cl₂

5: aq. NaOH / tetrahydrofuran

6: 63 percent / O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); N-hydroxybenzotriazole / acetonitrile / 20 °C

7: tetra-n-butylammonium fluoride

With pyridine; dmap; sodium hydroxide; sodium chlorite; 2-methyl-but-2-ene; O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); TEA; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1081/NCN-100002513

Reference yield:

: 131118-61-1
3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde

: 380615-24-7
2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / pyridine / 12 h / 100 °C

2: sodium cyanoborohydride / methanol; acetic acid / 6 h / 20 °C

3: 63 percent / O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); N-hydroxybenzotriazole / acetonitrile / 20 °C

4: tetra-n-butylammonium fluoride

With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); tetrabutyl ammonium fluoride; sodium cyanoborohydride; benzotriazol-1-ol; In methanol; acetic acid; acetonitrile;
DOI:10.1081/NCN-100002513

Reference yield:

: 195519-90-5
[(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

: 380615-24-7
2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); N-hydroxybenzotriazole / acetonitrile / 20 °C

2: tetra-n-butylammonium fluoride

With O-(1H-benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₆^(1-); tetrabutyl ammonium fluoride; benzotriazol-1-ol; In acetonitrile;
DOI:10.1081/NCN-100002513