1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine

Base Information

Chemical Name:1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine
CAS No.:121743-40-6
Molecular Formula:C₁₅H₁₉NO₂
Molecular Weight:245.321
Hs Code.:

Synonyms:

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Chemical Property of 1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine

Chemical Property:

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Technology Process of 1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine

There total 7 articles about 1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4411-89-6,54075-10-4,54075-09-1
2-phenyl-2-butenal

: 121743-40-6
1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) sodium borohydride / 1.) CCl₄, 78-80 deg C, 12 d, 2.) methanol, 10 min

2: 78 percent / trifluoroacetic acid

3: 1.) N-methylmorpholine, diphenylphosphinic chloride, 2.) tetramethylguanidinium azide / 1.) -23 deg C, CH₂Cl₂, 0,5 h, 2.) CH₂Cl₂, 0.5 h -> 0 deg C, 2 h

4: benzene / 1.7 h / 65 - 70 °C

5: 71 percent / diethyl ether / Ambient temperature

6: 1.) NaOH, 2.) 90percent formic acid, 40percent formaldehyde / 1.) methanol, reflux, 2.) 30 min, reflux

With 4-methyl-morpholine; sodium hydroxide; sodium tetrahydroborate; formaldehyd; formic acid; tetramethylguanidinum azide; trifluoroacetic acid; Diphenylphosphinic chloride; In diethyl ether; benzene;
DOI:10.1016/0040-4020(89)80052-3

Reference yield:

: 122-78-1
phenylacetaldehyde

: 121743-40-6
1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 41 percent / sodium acetate / ethanol; H₂O / 1 h, r.t., 4 h, reflux, cooled overnight

2: 2.) sodium borohydride / 1.) CCl₄, 78-80 deg C, 12 d, 2.) methanol, 10 min

3: 78 percent / trifluoroacetic acid

4: 1.) N-methylmorpholine, diphenylphosphinic chloride, 2.) tetramethylguanidinium azide / 1.) -23 deg C, CH₂Cl₂, 0,5 h, 2.) CH₂Cl₂, 0.5 h -> 0 deg C, 2 h

5: benzene / 1.7 h / 65 - 70 °C

6: 71 percent / diethyl ether / Ambient temperature

7: 1.) NaOH, 2.) 90percent formic acid, 40percent formaldehyde / 1.) methanol, reflux, 2.) 30 min, reflux

With 4-methyl-morpholine; sodium hydroxide; sodium tetrahydroborate; formaldehyd; formic acid; sodium acetate; tetramethylguanidinum azide; trifluoroacetic acid; Diphenylphosphinic chloride; In diethyl ether; ethanol; water; benzene;
DOI:10.1016/0040-4020(89)80052-3

Reference yield:

: (2E,4Z)-2-Isocyanatomethyl-4-phenyl-hexa-2,4-dienoic acid methyl ester

: 121743-40-6
1,2-dimethyl-5-methoxycarbonyl-3-phenyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / diethyl ether / Ambient temperature

2: 1.) NaOH, 2.) 90percent formic acid, 40percent formaldehyde / 1.) methanol, reflux, 2.) 30 min, reflux

With sodium hydroxide; formaldehyd; formic acid; In diethyl ether;
DOI:10.1016/0040-4020(89)80052-3