3-((4-(6-chloro-2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Base Information

• Chemical Name: 3-((4-(6-chloro-2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole
• CAS No.: 1402709-69-6
• Molecular Formula: C₂₆H₃₀ClFN₈O
• Molecular Weight: 525.029
• Mol file: 1402709-69-6.mol

Synonyms:

Chemical Property of 3-((4-(6-chloro-2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4-(6-chloro-2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

There total 2 articles about 3-((4-(6-chloro-2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-4-[4-(5-methyl-isoxazol-3-ylmethyl)piperazin-1-yl]-3-nitro-pyridin-2-ylamine (942949-34-0) + 3-fluoro-4-(4-methylpiperazin-1-yl)benzaldehyde (868770-03-0) → 3-((4-(6-chloro-2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole (1402709-69-6)

Guidance literature:

With sodium dithionite; In ethanol; water; for 24h; Reflux;

DOI:10.1021/jm300952s

Reference yield:

3,4 difluorobenzaldehyde (34036-07-2) + N-methylpiperazine dihydrochloride (50398-09-9,51545-09-6,34352-59-5) → 3-((4-(6-chloro-2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole (1402709-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 120 °C

2: sodium dithionite / ethanol; water / 24 h / Reflux

With sodium dithionite; N-ethyl-N,N-diisopropylamine; In ethanol; water; dimethyl sulfoxide;

DOI:10.1021/jm300952s

upstream raw materials:

3,4 difluorobenzaldehyde

N-methylpiperazine dihydrochloride

5-chloro-4-[4-(5-methyl-isoxazol-3-ylmethyl)piperazin-1-yl]-3-nitro-pyridin-2-ylamine

3-fluoro-4-(4-methylpiperazin-1-yl)benzaldehyde