7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid

Base Information

Chemical Name:7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid
CAS No.:134426-60-1
Molecular Formula:C₃₈H₃₀N₆O₁₁S₂
Molecular Weight:810.822
Hs Code.:

7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid

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Chemical Property of 7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid

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Technology Process of 7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid

There total 8 articles about 7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4821-94-7
4,5-dimethoxyphthalic anhydride

: 134426-60-1
7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.7 g / NH₄OH / Heating

2: 1.) BBr₃, 2.) H₂O / 1.) CH₂Cl₂, 2.) CH₂Cl₂, RT, 45 min

3: 3 h / 160 °C

4: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 3 h

5: 70 mg / Et₃N / dimethylsulfoxide / 1.5 h / Ambient temperature

With ammonium hydroxide; water; boron tribromide; sodium hydride; triethylamine; In dimethyl sulfoxide;
DOI:10.7164/antibiotics.46.1458

Reference yield:

: 4764-20-9
4,5-dimethoxyphthalimide

: 134426-60-1
7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BBr₃, 2.) H₂O / 1.) CH₂Cl₂, 2.) CH₂Cl₂, RT, 45 min

2: 3 h / 160 °C

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 3 h

4: 70 mg / Et₃N / dimethylsulfoxide / 1.5 h / Ambient temperature

With water; boron tribromide; sodium hydride; triethylamine; In dimethyl sulfoxide;
DOI:10.7164/antibiotics.46.1458

Reference yield:

: 577-68-4
m-hemipinic acid

: 134426-60-1
7-<2-(2-aminothiazol-4-yl)-2-((Z)-1-carboxy-1-methylethoxyimino)acetamido>-3-(5,6-diphenylmethylenedioxy-1,3-dioxo-isoindol-2-ylmethyl)ceph-3-em-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.28 g / Ac₂O / 1 h / Heating

2: 1.7 g / NH₄OH / Heating

3: 1.) BBr₃, 2.) H₂O / 1.) CH₂Cl₂, 2.) CH₂Cl₂, RT, 45 min

4: 3 h / 160 °C

5: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 3 h

6: 70 mg / Et₃N / dimethylsulfoxide / 1.5 h / Ambient temperature

With ammonium hydroxide; water; acetic anhydride; boron tribromide; sodium hydride; triethylamine; In dimethyl sulfoxide;
DOI:10.7164/antibiotics.46.1458