3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester

Base Information

Chemical Name:3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester
CAS No.:123913-96-2
Molecular Formula:C₁₈H₁₈O₈
Molecular Weight:362.336
Hs Code.:

Synonyms:

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Chemical Property of 3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester

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Technology Process of 3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester

There total 8 articles about 3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 123913-96-2
3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / KOH / dibenzo-18-crown-6 / acetonitrile / 6 h / Ambient temperature

2: m-chloroperbenzoic acid, KF / CH₂Cl₂ / 42 h / Ambient temperature

3: aq. NaOH / 0.5 h / Ambient temperature

4: 94 percent / tert-BuOK / dibenzo-18-crown-6 / acetonitrile / 14 h / Ambient temperature

5: 53 percent / NaBH₄ / ethanol; tetrahydrofuran / 0.5 equivalent NaBH₄; -10 deg C, 45 min; -10 deg C to RT, 45 min

6: conc. HCl / methanol / 0.5 h / Heating

With hydrogenchloride; potassium fluoride; potassium hydroxide; sodium tetrahydroborate; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; dibenzo-18-crown-6; In tetrahydrofuran; methanol; sodium hydroxide; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 124555-63-1
4-methoxy-2-methoxymethoxy benzaldehyde

: 123913-96-2
3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: m-chloroperbenzoic acid, KF / CH₂Cl₂ / 42 h / Ambient temperature

2: aq. NaOH / 0.5 h / Ambient temperature

3: 94 percent / tert-BuOK / dibenzo-18-crown-6 / acetonitrile / 14 h / Ambient temperature

4: 53 percent / NaBH₄ / ethanol; tetrahydrofuran / 0.5 equivalent NaBH₄; -10 deg C, 45 min; -10 deg C to RT, 45 min

5: conc. HCl / methanol / 0.5 h / Heating

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; dibenzo-18-crown-6; In tetrahydrofuran; methanol; sodium hydroxide; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 54011-33-5
3-(3,4-methylenedioxyphenyl)-3-oxopropionic acid methyl ester

: 123913-96-2
3-Benzo[1,3]dioxol-5-yl-3-hydroxy-2-(2-hydroxy-4-methoxy-phenoxy)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / Br₂ / CHCl₃ / below 20 deg C

2: 94 percent / tert-BuOK / dibenzo-18-crown-6 / acetonitrile / 14 h / Ambient temperature

3: 53 percent / NaBH₄ / ethanol; tetrahydrofuran / 0.5 equivalent NaBH₄; -10 deg C, 45 min; -10 deg C to RT, 45 min

4: conc. HCl / methanol / 0.5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium tert-butylate; bromine; dibenzo-18-crown-6; In tetrahydrofuran; methanol; ethanol; chloroform; acetonitrile;