methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate

Base Information

• Chemical Name: methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate
• CAS No.: 2243961-42-2
• Molecular Formula: C₁₇H₂₄N₂O₆
• Molecular Weight: 352.387
• Mol file: 2243961-42-2.mol

Synonyms:

Chemical Property of methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate

There total 1 articles about methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl 5-amino-2-pyridinecarboxylate (67515-76-8) → methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate (2243961-42-2)

Guidance literature:

With dmap; In acetonitrile; at 20 ℃;

Reference yield: 72.0%

methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate (2243961-42-2) → tert-butyl N-[6-(hydroxymethyl)pyridin-3-yl]carbamate (323578-38-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; Reflux;

Reference yield:

methyl 5-(N,N-di-tert-butyloxycarbonyl)amino-2-pyridinecarboxylate (2243961-42-2) → tert-butyl (6-(((tert-butyldiphenylsilyl)oxy)methyl)pyridin-3-yl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / Reflux

2: 1H-imidazole / dichloromethane

With 1H-imidazole; sodium tetrahydroborate; In methanol; dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

methyl 5-amino-2-pyridinecarboxylate

Downstream raw materials:

tert-butyl N-[6-(hydroxymethyl)pyridin-3-yl]carbamate

Refernces