Technology Process of tert-butyl 3-<6'-(benzyloxy)-2',4'-dimethylfuro<2,3-b>-pyrid-5'-yl>-3-hydroxybutanoate
There total 12 articles about tert-butyl 3-<6'-(benzyloxy)-2',4'-dimethylfuro<2,3-b>-pyrid-5'-yl>-3-hydroxybutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 74 percent / aq. ammonia / 120 h / Ambient temperature
2: 76 percent / trifluoroacetic acid / 6 h / Heating
3: 87 percent / silver carbonate / tetrahydrofuran / 5 h / Heating
4: 67 percent / diisobutylaluminum hydride / hexane; dioxane / 50 °C
5: 100 percent / diethyl ether; tetrahydrofuran / 0.25 h / 0 °C
6: 67 percent / pyridinium dichromate / dimethylformamide / 4 h / 5 °C
7: Mg / tetrahydrofuran / 3 h / 50 °C
With
ammonium hydroxide; dipyridinium dichromate; diisobutylaluminium hydride; magnesium; silver carbonate; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo00290a019
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 30 percent / sodium ethoxide / ethanol / 12 h / Heating
2: tetrahydrofuran / 21 h
3: 1) NaIO4 / 40percent water/dioxane, 1) 3.5 h, 0 deg C, 2) 15 h, reflux
4: 87 percent / silver carbonate / tetrahydrofuran / 5 h / Heating
5: 67 percent / diisobutylaluminum hydride / hexane; dioxane / 50 °C
6: 100 percent / diethyl ether; tetrahydrofuran / 0.25 h / 0 °C
7: 67 percent / pyridinium dichromate / dimethylformamide / 4 h / 5 °C
8: Mg / tetrahydrofuran / 3 h / 50 °C
With
sodium periodate; dipyridinium dichromate; sodium ethanolate; diisobutylaluminium hydride; magnesium; silver carbonate;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo00290a019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrahydrofuran / 21 h
2: 1) NaIO4 / 40percent water/dioxane, 1) 3.5 h, 0 deg C, 2) 15 h, reflux
3: 87 percent / silver carbonate / tetrahydrofuran / 5 h / Heating
4: 67 percent / diisobutylaluminum hydride / hexane; dioxane / 50 °C
5: 100 percent / diethyl ether; tetrahydrofuran / 0.25 h / 0 °C
6: 67 percent / pyridinium dichromate / dimethylformamide / 4 h / 5 °C
7: Mg / tetrahydrofuran / 3 h / 50 °C
With
sodium periodate; dipyridinium dichromate; diisobutylaluminium hydride; magnesium; silver carbonate;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo00290a019
