124098-58-4

Upstream product

• 5977-14-0 acetoacetamido 
• 106-95-6 allyl bromide 
• 107-18-6 allyl alcohol 
• 107-11-9 1-amino-2-propene 

Downstream Products

• 124098-56-2 3,4,5,5',8-pentamethyl-8-azapsoralen triflate 
• 124098-54-0 4,5,5',8-tetramethyl-8-azapsoralen triflate 
• 124125-51-5 3,5,5',8-tetramethyl-8-azapsoralen triflate 
• 124098-52-8 5,5',8-trimethyl-8-azapsoralen triflate 
• 124098-71-1 tert-butyl 3-<6'-(benzyloxy)-2',4'-dimethylfuro<2,3-b>-pyrid-5'-yl>-3-hydroxybutanoate 
• 124098-69-7 tert-butyl 3-<6'-(benzyloxy)-2',4'-dimethylfuro<2,3-b>-pyrid-5'-yl>-3-hydroxy-2-methylpropanoate 
• 124125-52-6 tert-butyl 3-<6'-(benzyloxy)-2',4'-dimethylfuro<2,3-b>-pyrid-5'-yl>-3-hydroxybutanoate 
• 124098-65-3 3-<6'-(benzyloxy)-2',4'-dimethylfuro<2,3-b>pyrid-5'-yl>-propenoic acid 
• 124098-68-6 5-acetyl-6-(benzyloxy)-2,4-dimethylfuro<2,3-b>pyridine 
• 124098-67-5 5-(1-hydroxyethyl)-6-(benzyloxy)-2,4-dimethylfuro<2,3-b>pyridine 
• 124098-57-3 2-<(phenylseleno)methyl>-5-cyano-6-hydroxy-4-methyl-1,2-dihydrofuro<2,3-b>pyridine 
• 124098-63-1 7-benzyl-5-cyano-6,7-dihydro-2,4-dimethyl-6-oxofuro<2,3-b>pyridine 
• 124098-62-0 6-(benzyloxy)-5-cyano-2,4-dimethylfuro<2,3-b>pyridine 
• 124098-64-2 6-(benzyloxy)-2,4-dimethylfuro<2,3-b>pyridine-5-carboxaldehyde 

Relevant academic research and scientific papers

Catalytic C?C Bond Formation Using a Simple Nickel Precatalyst System: Base- and Activator-Free Direct C-Allylation by Alcohols and Amines

A “totally catalytic” nickel(0)-mediated method for base-free direct alkylation of allyl alcohols and allyl amines is reported. The reaction is selective for monoallylation, uses an inexpensive NiII precatalyst system, and requires no activating reagents to be present.

Azapsoralens. Synthesis of 8-Azapsoralens

The synthesis of some N-methyl-8-azapsoralen salts 1 is described for use as water-soluble analogues of psoralens.A key intermediate is the furopyridine carboxaldehyde 16 prepared in four steps from simple acyclic precursors.The pyrone ring is fused on by first extending the carbon chain via a Reformatsky or Doebner condensation followed by deprotection and ring closure.Since stability of this ring system in water is crucial to its potential use as a nucleic acid cross-linking reagent, rates of pyrone hydrolysis for the N-methylazapsoralens were measured.Sufficient stability in the necessary pH range was found for several analogues.