Technology Process of 4-Penten-2-ynoic acid, 5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, methyl
ester, (E)-
There total 1 articles about 4-Penten-2-ynoic acid, 5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, methyl
ester, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
Yield given. Multistep reaction;
1.) diethyl ether, hexane, from -70 deg C to -50 deg C, 2.) diethyl ether, hexane, a) -30 deg C, 2 h, b) RT, 4 h;
DOI:10.1021/jo00379a016
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) copper(I) iodide / 1.) THF, pentane, -30 deg C, 2.) THF, pentane, -20 deg C, 2 h
2: 87 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
3: 72 percent / MnO2 / diethyl ether / 17 h / Ambient temperature
4: 1.) NaH / 1.) THF, 1 h, 2.) THF, Et2O, RT, 3 h
5: diisobutylaluminum hydride (DIBAH) / hexane / 3 h / Ambient temperature
With
manganese(IV) oxide; copper(l) iodide; lithium aluminium tetrahydride; sodium hydride; diisobutylaluminium hydride;
In
diethyl ether; hexane;
DOI:10.1021/jo00379a016
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) copper(I) iodide / 1.) THF, pentane, -30 deg C, 2.) THF, pentane, -20 deg C, 2 h
2: 87 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
3: 72 percent / MnO2 / diethyl ether / 17 h / Ambient temperature
4: 1.) NaH / 1.) THF, 1 h, 2.) THF, Et2O, RT, 3 h
5: diisobutylaluminum hydride (DIBAH) / hexane / 3 h / Ambient temperature
With
manganese(IV) oxide; copper(l) iodide; lithium aluminium tetrahydride; sodium hydride; diisobutylaluminium hydride;
In
diethyl ether; hexane;
DOI:10.1021/jo00379a016
