<6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole

Base Information

• Chemical Name: <6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole
• CAS No.: 131572-88-8
• Molecular Formula: C₂₈H₃₂N₂O₃S
• Molecular Weight: 476.64
• Mol file: 131572-88-8.mol

Synonyms:

Chemical Property of <6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole

There total 19 articles about <6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N-[(9S,10R)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,7,8,9,10-hexahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-90-2) → N-[(6aS,9R,10R,10aR)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,6a,7,8,9,10,10a-octahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5) + N-[(6aS,9S,10S,10aR)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,6a,7,8,9,10,10a-octahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5) + <6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5)

Guidance literature:

With triethylsilane; trifluoroacetic acid; for 14h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96007-7

Reference yield: 58.0%

N-[(9S,10R)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,7,8,9,10-hexahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-90-2) → N-[(6aS,9R,10R,10aR)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,6a,7,8,9,10,10a-octahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5) + N-[(6aS,9S,10S,10aR)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,6a,7,8,9,10,10a-octahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5) + <6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5)

Guidance literature:

With triethylsilane; trifluoroacetic acid; for 14h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96007-7

Reference yield: 58.0%

N-[(9S,10R)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,7,8,9,10-hexahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-90-2) → N-[(6aS,9R,10R,10aR)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,6a,7,8,9,10,10a-octahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5) + N-[(6aS,9S,10S,10aR)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,6a,7,8,9,10,10a-octahydro-2-aza-aceanthrylen-10-yl]-formamide (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5) + <6aR*-(6aβ,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole (131572-88-8,131616-33-6,131616-37-0,131616-38-1,131616-39-2,131616-40-5)

Guidance literature:

With triethylsilane; trifluoroacetic acid; for 14h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96007-7

upstream raw materials:

N-[(9S,10R)-6,6,9-Trimethyl-2-(toluene-4-sulfonyl)-9-vinyl-2,6,7,8,9,10-hexahydro-2-aza-aceanthrylen-10-yl]-formamide

<6aα*-(6aα,9α,10α,10aα)>-10-formamido-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-9-vinylnaphth<1.2.3-cd>indole

p-toluenesulfonyl chloride

<6aS*-(6aα,9α,10aβ)>-2,6,6a,7,8,9,10,10a-octahydro-6,6,9-trimethyl-10-oxo-2-p-toluenesulfonyl-9-vinylnaphth<1,2,3-cd>indole

Downstream raw materials:

<6aR*-(6aβ,9α,10α,10aβ)>-2,6,6a,7,8,9,10,10a-octahydro-10-isocyano-6,6,9-trimethyl-9-vinylnaphth<1,2,3-cd>indole

(+/-)-hapalindole U

(+/-)-hapalindole H