ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate

Base Information

• Chemical Name: ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate
• CAS No.: 1259313-20-6
• Molecular Formula: C₂₈H₄₄N₆O₄
• Molecular Weight: 528.695
• Mol file: 1259313-20-6.mol

Synonyms:

Chemical Property of ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate

There total 3 articles about ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

4-((2-(3,5-dimethylpyrazol-1-yl)ethyl)(2-ethoxy-2-oxoethyl)amino)butanoic acid (1259313-18-2) + 4-amino-N-(2-diethylaminoethyl)benzamide (51-06-9) → ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate (1259313-20-6)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; for 72h; Reflux; Inert atmosphere;

DOI:10.1039/c0nj00256a

Reference yield:

ethyl 2-((2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)amino)acetate (1259313-16-0) → ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate (1259313-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; potassium iodide / acetonitrile / 72 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 72 h / Reflux; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; potassium iodide; In ethanol; acetonitrile;

DOI:10.1039/c0nj00256a

Reference yield:

1-(2-bromoethyl)-3,5-dimethyl-1H-pyrazole (67000-35-5) → ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate (1259313-20-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 72 h / Reflux; Inert atmosphere

2: triethylamine; potassium iodide / acetonitrile / 72 h / Reflux; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 72 h / Reflux; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; potassium iodide; In ethanol; acetonitrile;

DOI:10.1039/c0nj00256a

upstream raw materials:

ethyl 2-((2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)amino)acetate

4-((2-(3,5-dimethylpyrazol-1-yl)ethyl)(2-ethoxy-2-oxoethyl)amino)butanoic acid

4-amino-N-(2-diethylaminoethyl)benzamide

1-(2-bromoethyl)-3,5-dimethyl-1H-pyrazole

Downstream raw materials:

ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid