ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

Base Information

• Chemical Name: ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid
• CAS No.: 1259313-36-4
• Molecular Formula: C₂₆H₄₀N₆O₄
• Molecular Weight: 500.641
• Mol file: 1259313-36-4.mol

Synonyms:

Chemical Property of ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid

There total 5 articles about ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate (1259313-20-6) → ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid (1259313-36-4)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1039/c0nj00256a

Reference yield:

ethyl 2-((2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)amino)acetate (1259313-16-0) → ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid (1259313-36-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; potassium iodide / acetonitrile / 72 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 72 h / Reflux; Inert atmosphere

4: water; sodium hydroxide / tetrahydrofuran / Reflux; Inert atmosphere

With palladium 10% on activated carbon; water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; potassium iodide; sodium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1039/c0nj00256a

Reference yield:

benzyl 4-((2-(3,5-dimethylpyrazol-1-yl)ethyl)(2-ethoxy-2-oxoethyl)amino)butanoate (1259313-17-1) → ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethypyrazol-1-yl)ethyl)amino)acetic acid (1259313-36-4)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 72 h / Reflux; Inert atmosphere

3: water; sodium hydroxide / tetrahydrofuran / Reflux; Inert atmosphere

With palladium 10% on activated carbon; water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1039/c0nj00256a

upstream raw materials:

ethyl 2-((4-(4-(2-(diethylamino)ethylcarbamoyl)phenylamino)-4-oxobutyl)(2-(3,5-dimethylpyrazol-1-yl)ethyl)amino)acetate

ethyl 2-((2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)amino)acetate

benzyl 4-((2-(3,5-dimethylpyrazol-1-yl)ethyl)(2-ethoxy-2-oxoethyl)amino)butanoate

4-((2-(3,5-dimethylpyrazol-1-yl)ethyl)(2-ethoxy-2-oxoethyl)amino)butanoic acid