(E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid

Base Information

• Chemical Name: (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid
• CAS No.: 100046-98-8
• Molecular Formula: C₁₇H₁₄O₄S
• Molecular Weight: 314.362
• Mol file: 100046-98-8.mol

Synonyms:

Chemical Property of (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid

There total 3 articles about (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophene-2-carbaldehyde (98-03-3) + dimethyl (E)-2-<(4-methylphenyl)methylene>butanedioate (100046-96-6) → (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid (100046-98-8)

Guidance literature:

With sodium ethanolate; In diethyl ether; at -15 - -10 ℃; for 48h;

Reference yield:

4-methyl-benzaldehyde (104-87-0) → (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid (100046-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOK / 2-methyl-propan-2-ol / 0.75 h / Heating

2: 95 percent / K₂CO₃ / acetone / Heating

3: EtONa / diethyl ether / 48 h / -15 - -10 °C

With potassium tert-butylate; sodium ethanolate; potassium carbonate; In diethyl ether; acetone; tert-butyl alcohol;

Reference yield:

(E)-3-(methoxycarbonyl)-4-(4-methylphenyl)-3-butenoic acid (100046-95-5) → (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic acid (100046-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / acetone / Heating

2: EtONa / diethyl ether / 48 h / -15 - -10 °C

With sodium ethanolate; potassium carbonate; In diethyl ether; acetone;

upstream raw materials:

thiophene-2-carbaldehyde

dimethyl (E)-2-<(4-methylphenyl)methylene>butanedioate

4-methyl-benzaldehyde

(E)-3-(methoxycarbonyl)-4-(4-methylphenyl)-3-butenoic acid

Downstream raw materials:

dimethyl (E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinate

(E,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic anhydride

(E,Z)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic anhydride

(Z,E)-2-<(4-methylphenyl)methylene>-3-(2-thienylmethylene)succinic anhydride

Refernces