2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol

Base Information

Chemical Name:2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol
CAS No.:1027499-81-5
Molecular Formula:C₂₆H₂₉NO₃
Molecular Weight:403.521
Hs Code.:

Synonyms:

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Chemical Property of 2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol

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Technology Process of 2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol

There total 8 articles about 2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 1027499-81-5
2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / Br₂; FeCl₃; AcOH

2: 77 percent / Pd(OAc)2; Ph₃P; aq. NaHCO₃ / dioxane / 12 h / Heating

3: 71 percent / tetrahexylammonium iodide; aq. NaOH / CH₂Cl₂

4: 88 percent / H₂ / Pd/C / methanol / 760 Torr

5: BH₃*SMe₂ / tetrahydrofuran

With palladium diacetate; sodium hydroxide; dimethylsulfide borane complex; hydrogen; bromine; iron(III) chloride; sodium hydrogencarbonate; tetrahexylammonium iodide; acetic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2: Suzuki coupling;
DOI:10.1021/jo049157q

Reference yield:

: 1074-16-4
2-bromophenylethyl alcohol

: 1027499-81-5
2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 72 percent / camphorsulfonic acid monohydrate / CH₂Cl₂ / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: trimethyl borate / tetrahydrofuran; hexane / 1.25 h / cooling

3.1: 77 percent / Pd(OAc)2; Ph₃P; aq. NaHCO₃ / dioxane / 12 h / Heating

4.1: 71 percent / tetrahexylammonium iodide; aq. NaOH / CH₂Cl₂

5.1: 88 percent / H₂ / Pd/C / methanol / 760 Torr

6.1: BH₃*SMe₂ / tetrahydrofuran

With palladium diacetate; sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; camphor-10-sulfonic acid; hydrogen; sodium hydrogencarbonate; tetrahexylammonium iodide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; 3.1: Suzuki coupling;
DOI:10.1021/jo049157q

Reference yield:

: 15930-53-7
6-bromo-3,4-methylenedioxybenzaldehyde

: 1027499-81-5
2-(2-{6-[3-((S)-1-Phenyl-ethylamino)-propyl]-benzo[1,3]dioxol-5-yl}-phenyl)-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / Pd(OAc)2; Ph₃P; aq. NaHCO₃ / dioxane / 12 h / Heating

2: 71 percent / tetrahexylammonium iodide; aq. NaOH / CH₂Cl₂

3: 88 percent / H₂ / Pd/C / methanol / 760 Torr

4: BH₃*SMe₂ / tetrahydrofuran

With palladium diacetate; sodium hydroxide; dimethylsulfide borane complex; hydrogen; sodium hydrogencarbonate; tetrahexylammonium iodide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 1: Suzuki coupling;
DOI:10.1021/jo049157q