2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione

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Chemical Name:2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione
CAS No.:263567-72-2
Molecular Formula:C₃₁H₃₄F₃N₃O₅
Molecular Weight:585.623
Hs Code.:

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Chemical Property of 2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione

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Technology Process of 2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione

There total 8 articles about 2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 263567-72-2
2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: toluene; tetrahydrofuran / 48 h

5.1: DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

7.1: TFA / CH₂Cl₂ / 8 h

8.1: tetrahydrofuran / 0.5 h / -5 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Condensation / 7.1: acidolysis / 8.1: Cyclization;
DOI:10.1021/jm990476x

Reference yield:

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 263567-72-2
2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: toluene; tetrahydrofuran / 48 h

3.1: DIBAL / diethyl ether / 0.5 h / -78 °C

4.1: diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

5.1: TFA / CH₂Cl₂ / 8 h

6.1: tetrahydrofuran / 0.5 h / -5 °C

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction / 4.1: Condensation / 5.1: acidolysis / 6.1: Cyclization;
DOI:10.1021/jm990476x

Reference yield:

: 475480-98-9
4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide

: 263567-72-2
2-((E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-[1,2,4]oxadiazolidine-3,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

2.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

3.1: NaH / toluene / 1 h

3.2: toluene; tetrahydrofuran / 48 h

4.1: DIBAL / diethyl ether / 0.5 h / -78 °C

5.1: diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

6.1: TFA / CH₂Cl₂ / 8 h

7.1: tetrahydrofuran / 0.5 h / -5 °C

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 1.1: Chlorination / 2.1: Alkylation / 3.1: Metallation / 3.2: Condensation / 4.1: Reduction / 5.1: Condensation / 6.1: acidolysis / 7.1: Cyclization;
DOI:10.1021/jm990476x