Phenol, 2-[(6-chloro-3-pyridazinyl)oxy]-

Base Information

• Chemical Name: Phenol, 2-[(6-chloro-3-pyridazinyl)oxy]-
• CAS No.: 106153-67-7
• Molecular Formula: C10H7ClN2O2
• Molecular Weight: 222.631
• DSSTox Substance ID: DTXSID90439623
• Nikkaji Number: J2.186.217G
• Wikidata: Q82255626
• Mol file: 106153-67-7.mol

Synonyms:2-(6-chloropyridazin-3-yl)oxyphenol;Phenol, 2-[(6-chloro-3-pyridazinyl)oxy]-;106153-67-7;SCHEMBL10621238;DTXSID90439623;IMJNLNABPWVSPG-UHFFFAOYSA-N;2-(6-Chloro-3-pyridazinyloxy)phenol;3-Chloro-6-(2-hydroxyphenoxy)pyridazine

Chemical Property of Phenol, 2-[(6-chloro-3-pyridazinyl)oxy]-

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 222.0196052
• Heavy Atom Count: 15
• Complexity: 206

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)O)OC2=NN=C(C=C2)Cl

Technology Process of Phenol, 2-[(6-chloro-3-pyridazinyl)oxy]-

There total 2 articles about Phenol, 2-[(6-chloro-3-pyridazinyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,6-dichlorpyridazine (141-30-0) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 1,2-bis[[6-chloropyridazin-3-yl]oxy]benzene + 6-chloropyridazin-3-yl-2-hydroxyphenyl ether (106153-67-7)

Guidance literature:

With potassium carbonate; In acetonitrile; for 25h; Heating;

DOI:10.1002/jhet.5570420425

Reference yield: 46.5%

3,6-dichlorpyridazine (141-30-0) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 6-chloropyridazin-3-yl-2-hydroxyphenyl ether (106153-67-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1248/cpb.42.1609

Reference yield: 63.6%

6-chloropyridazin-3-yl-2-hydroxyphenyl ether (106153-67-7) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 3-Chloro-6-(2-oxiranylmethoxy-phenoxy)-pyridazine (160951-18-8)

Guidance literature:

With potassium carbonate; for 2h; Heating;

DOI:10.1248/cpb.42.1609

upstream raw materials:

3,6-dichlorpyridazine

benzene-1,2-diol

Downstream raw materials:

3-Chloro-6-(2-oxiranylmethoxy-phenoxy)-pyridazine

1-[2-(6-Chloro-pyridazin-3-yloxy)-phenoxy]-3-isopropylamino-propan-2-ol