5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol

Base Information

• Chemical Name: 5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol
• CAS No.: 911836-37-8
• Molecular Formula: C₁₆H₁₅BrO
• Molecular Weight: 303.198
• Mol file: 911836-37-8.mol

Synonyms:

Chemical Property of 5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol

There total 1 articles about 5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-1-tetralone (68449-30-9) + phenylmagnesium bromide → 5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol (911836-37-8)

Guidance literature:

In tetrahydrofuran; cooling;

DOI:10.1021/ol061701p

Reference yield:

5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol (911836-37-8) → 1',2'-dideoxy-1'-β-(5-phenylnaphth-1-yl)-ribose

Guidance literature:

Multi-step reaction with 5 steps

1.1: 50 mg / TFA; triphenylmethanol / 48 h

2.1: magnesium; iodine / tetrahydrofuran / 40 °C

2.2: aluminum chloride / tetrahydrofuran / 2 h / 20 °C

2.3: 147 mg / tetrahydrofuran; CH₂Cl₂ / 3 h / cooling

3.1: 80 percent / CH₂Cl₂ / 24 h

4.1: 86 percent / (trimethylsilyl)silane; AIBN / toluene / Heating

5.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / cooling

With triphenylmethyl alcohol; 2,2'-azobis(isobutyronitrile); 1,1,1-trimethyldisilane; tetrabutyl ammonium fluoride; iodine; magnesium; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ol061701p

Reference yield:

5-bromo-1-phenyl-1,2,3,4-tetrahydro-naphthalen-1-ol (911836-37-8) → 1',2'-dideoxy-1'-β-(5-phenylnaphth-1-yl)-3',5'-bis-O-tert-butyldimethylsilyl-ribose (911836-33-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 50 mg / TFA; triphenylmethanol / 48 h

2.1: magnesium; iodine / tetrahydrofuran / 40 °C

2.2: aluminum chloride / tetrahydrofuran / 2 h / 20 °C

2.3: 147 mg / tetrahydrofuran; CH₂Cl₂ / 3 h / cooling

3.1: 80 percent / CH₂Cl₂ / 24 h

4.1: 86 percent / (trimethylsilyl)silane; AIBN / toluene / Heating

With triphenylmethyl alcohol; 2,2'-azobis(isobutyronitrile); 1,1,1-trimethyldisilane; iodine; magnesium; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ol061701p

upstream raw materials:

5-bromo-1-tetralone

Downstream raw materials:

1-bromo-5-phenylnaphthalene

1',2'-dideoxy-1'-β-(5-phenylnaphth-1-yl)-3',5'-bis-O-tert-butyldimethylsilyl-ribose

1'-deoxy-1'-β-(5-phenylnaphth-1-yl)-3',5'-bis-O-tert-butyldimethylsilyl-arabinose

1'-deoxy-1'-β-(5-phenylnaphth-1-yl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-O-thionocarbonylimidazolyl-arabinose