-<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

Base Information

• Chemical Name: -<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester
• CAS No.: 141956-51-6
• Molecular Formula: C₃₇H₄₉N₄O₆P
• Molecular Weight: 676.793

Synonyms:

Chemical Property of -<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

Chemical Property:

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Technology Process of -<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

There total 2 articles about -<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

Diethyl methylphosphonate (683-08-9) + -<2-<<2-<(3-bromo-1-oxopropyl)amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-49-2) → -<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-51-6,142035-19-6)

Guidance literature:

In toluene; at 110 ℃; for 2h;

DOI:10.1021/jm00092a007

Reference yield:

tricyclo<3.3.1.13,7>dec-2-yl *,R*)>-<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate (130406-64-3) → -<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-51-6,142035-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) pentafluorophenol (PFP), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) EtOAc, RT, 2 h, 2.) EtOAc, RT, overnight

2: 55 percent / toluene / 2 h / 110 °C

With 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; In toluene;

DOI:10.1021/jm00092a007

Reference yield:

-<2-<<2-<<3-(ethoxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-51-6,142035-19-6) → -<2-<<2-<<3-(hydroxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.13,7>dec-2-yl ester (141956-53-8)

Guidance literature:

With trimethylsilyl bromide; water; Yield given. Multistep reaction; 1.) CH₂Cl₂, RT, 36 h, 2.) MeOH, RT, 24 h;

DOI:10.1021/jm00092a007

upstream raw materials:

Diethyl methylphosphonate

-<2-<<2-<(3-bromo-1-oxopropyl)amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

tricyclo<3.3.1.1^3,7>dec-2-yl *,R^*)>-<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

Downstream raw materials:

-<2-<<2-<<3-(hydroxymethylphosphinyl)-1-oxopropyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamic acid tricyclo<3.3.1.1^3,7>dec-2-yl ester

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