1-(Benzenesulfonyl)-N-tert-butyl-1H-indole-2-carboxamide

Base Information

• Chemical Name: 1-(Benzenesulfonyl)-N-tert-butyl-1H-indole-2-carboxamide
• CAS No.: 106154-54-5
• Molecular Formula: C19H20N2O3S
• Molecular Weight: 356.445
• DSSTox Substance ID: DTXSID30546961
• Wikidata: Q82424937
• Mol file: 106154-54-5.mol

Synonyms:106154-54-5;1-(Benzenesulfonyl)-N-tert-butyl-1H-indole-2-carboxamide;N-(tert-Butyl)-1-(phenylsulfonyl)-1H-indole-2-carboxamide;DTXSID30546961

Chemical Property of 1-(Benzenesulfonyl)-N-tert-butyl-1H-indole-2-carboxamide

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 356.11946368
• Heavy Atom Count: 25
• Complexity: 585

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)NC(=O)C1=CC2=CC=CC=C2N1S(=O)(=O)C3=CC=CC=C3

Technology Process of 1-(Benzenesulfonyl)-N-tert-butyl-1H-indole-2-carboxamide

There total 4 articles about 1-(Benzenesulfonyl)-N-tert-butyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-benzenesulfonylindole (40899-71-6) + Tert-butyl isocyanate (1609-86-5) → 2-(butylaminocarbonyl)-1-(phenylsulfonyl)indole (106154-54-5)

Guidance literature:

1-benzenesulfonylindole; With lithium diisopropyl amide; In tetrahydrofuran;

Tert-butyl isocyanate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2013.09.012

Reference yield: 83.0%

1-(benzenesulfonyl)-2-lithioindole (40900-03-6) + Tert-butyl isocyanate (1609-86-5) → 2-(butylaminocarbonyl)-1-(phenylsulfonyl)indole (106154-54-5)

Guidance literature:

Reference yield:

indole (120-72-9) → 2-(butylaminocarbonyl)-1-(phenylsulfonyl)indole (106154-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi

2: 1.) n-BuLi, (i-Pr)NH / 1.) THF, -78 deg C, 15 min., then -78 deg C, 1 h and -5 deg C, 20 min, 2.) THF, -78 deg C, 2 h, then to room t., 4 h

With n-butyllithium; (i-Pr)NH;

DOI:10.1016/S0040-4020(01)85951-2

upstream raw materials:

1-benzenesulfonylindole

Tert-butyl isocyanate

1-(benzenesulfonyl)-2-lithioindole

indole

Downstream raw materials:

1-(Phenylsulfonyl)indole-2-carbonitrile