(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone

Base Information

• Chemical Name: (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone
• CAS No.: 1636166-41-0
• Molecular Formula: C₂₁H₁₉ClF₃N₅O₄S
• Molecular Weight: 529.927
• Mol file: 1636166-41-0.mol

Synonyms:

Chemical Property of (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone

There total 5 articles about (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid (1636166-31-8) → (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone (1636166-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / 1,2-dichloro-ethane / 3 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / 1,2-dichloro-ethane / 6 h / Reflux

3: triethylamine / 1,2-dichloro-ethane / 3 h / Reflux

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In 1,2-dichloro-ethane;

DOI:10.5935/0103-5053.20140073

Reference yield:

tert-butyl 4-(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carbonyl)piperazine-1-carboxylate (1636166-32-9) → (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone (1636166-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1,2-dichloro-ethane / 6 h / Reflux

2: triethylamine / 1,2-dichloro-ethane / 3 h / Reflux

With triethylamine; trifluoroacetic acid; In 1,2-dichloro-ethane;

DOI:10.5935/0103-5053.20140073

Reference yield:

methyl 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-4-carboxylate (1636166-29-4) → (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone (1636166-41-0)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium acetate; trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 6 h / Inert atmosphere; Heating

2: sodium hydroxide / water; tetrahydrofuran / 7 h / 20 °C

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / 1,2-dichloro-ethane / 3 h / Inert atmosphere; Reflux

4: trifluoroacetic acid / 1,2-dichloro-ethane / 6 h / Reflux

5: triethylamine / 1,2-dichloro-ethane / 3 h / Reflux

With trans-bis(triphenylphosphine)palladium dichloride; potassium acetate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane;

DOI:10.5935/0103-5053.20140073

upstream raw materials:

6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

tert-butyl 4-(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carbonyl)piperazine-1-carboxylate

methyl-6-chloro-2-methylpyrimidine-4-carboxylate

methyl 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-4-carboxylate