(S)-1-Benzyl-3-chloro-piperidine

Base Information

• Chemical Name: (S)-1-Benzyl-3-chloro-piperidine
• CAS No.: 1354017-94-9
• Molecular Formula: C₁₂H₁₆ClN
• Molecular Weight: 209.719
• Mol file: 1354017-94-9.mol

Synonyms:

Chemical Property of (S)-1-Benzyl-3-chloro-piperidine

Chemical Property:

Purity/Quality:

(S)-1-Benzyl-3-chloropiperidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-Benzyl-3-chloro-piperidine

There total 13 articles about (S)-1-Benzyl-3-chloro-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-N-benzylprolinol (53912-80-4) → (-)-(3R)-1-benzyl-3-chloropiperidine (240132-25-6,1354017-94-9)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1021/jo900031e

Reference yield: 82.0%

N-benzylpent-4-en-1-amine (54436-58-7) → 1-benzyl-3-chloropiperidine (54436-59-8,1354017-94-9)

Guidance literature:

With copper(II) choride dihydrate; In tetrahydrofuran; at 20 ℃; for 21h; Reflux;

DOI:10.1016/j.tet.2013.05.022

Reference yield: 56.0%

N-benzylpent-4-en-1-amine (54436-58-7) → 1-benzyl-2-(chloromethyl)pyrrolidine (128574-35-6,1226950-67-9,161564-02-9) + 1-benzyl-3-chloropiperidine (54436-59-8,1354017-94-9)

Guidance literature:

With copper(II) chloride dihydrate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1002/adsc.201200352

upstream raw materials:

(S)-N-benzylprolinol

1-azabicyclo[3.1.0]hexane

benzyl chloride

N-benzylpent-4-en-1-amine

Refernces

• 1、 Helbing, Tim,Georg, Mats,St?hr, Fabian,Carraro, Caterina,Becker, Jonathan,Gatto, Barbara,G?ttlich, Richard. "Understanding the Alkylation Mechanism of 3-Chloropiperidines – NMR Kinetic Studies and Isolation of Bicyclic Aziridinium Ions". . p. 5905 - 5913. Retrieved 2021/10/29.
• 2、 Liu, Gong-Qing,Li, Wei,Li, Yue-Ming. "A new method for intramolecular chloroamination of unfunctionalized olefins". supporting information. p. 395 - 402. Retrieved 2013/05/08.