(R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

Base Information

• Chemical Name: (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide
• CAS No.: 1235560-83-4
• Molecular Formula: C₂₁H₂₂ClF₂N₃O₃S
• Molecular Weight: 469.94
• Mol file: 1235560-83-4.mol

Synonyms:

Chemical Property of (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

There total 4 articles about (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-N-methylaniline (1978-38-7) + (R)-4-chloro-2-fluoro-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzene-1-sulfonyl chloride → (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide (1235560-83-4)

Guidance literature:

2-fluoro-N-methylaniline; (R)-4-chloro-2-fluoro-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzene-1-sulfonyl chloride; In dichloromethane; at 20 ℃;

With sodium carbonate; In methanol; dichloromethane; for 0.5h;

DOI:10.1021/acsmedchemlett.5b00023

Reference yield:

2-chloro-5-(chlorosulfonyl)-4-fluorobenzoic acid (264927-50-6) → (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide (1235560-83-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: dichloromethane / 1 h / 20 °C

2.2: 20 °C

3.1: dichloromethane / 20 °C

3.2: 0.5 h

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/acsmedchemlett.5b00023

Reference yield:

2-chloro-5-( chlorosulfonyl)-4-fluorobenzoyl chloride (866763-17-9) → (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-N-methyl-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide (1235560-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1 h / 20 °C

1.2: 20 °C

2.1: dichloromethane / 20 °C

2.2: 0.5 h

In dichloromethane;

DOI:10.1021/acsmedchemlett.5b00023

upstream raw materials:

2-chloro-5-(chlorosulfonyl)-4-fluorobenzoic acid

2-chloro-5-( chlorosulfonyl)-4-fluorobenzoyl chloride

2-fluoro-N-methylaniline