methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside

Base Information

• Chemical Name: methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside
• CAS No.: 73448-32-5
• Molecular Formula: C₂₄H₃₁NO₁₃
• Molecular Weight: 541.509
• Mol file: 73448-32-5.mol

Synonyms:methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside

Chemical Property of methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 917.8°C at 760 mmHg
• Flash Point: 508.9°C
• Density: 1.58g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside

There total 6 articles about methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

uridine-5'-diphosphogalactose (133-89-1,2956-16-3,7307-71-3,7349-77-1,16375-64-7,16375-65-8,16414-46-3,17012-87-2,25318-68-7,78391-94-3,99020-05-0,99945-86-5) + N-[(2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-3-yl]-acetamide (37067-30-4) → 4-methylumbelliferyl β-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside (73448-32-5)

Guidance literature:

With galactosyltransferase from Helicobacter pylori; In dimethyl sulfoxide; at 22 ℃; for 13h; pH=8; Enzymatic reaction;

DOI:10.1021/acschembio.8b01123

Reference yield: 74.0%

N-[(2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-3-yl]-acetamide (37067-30-4) + C15H25N3O16P2 → 4-methylumbelliferyl β-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside (73448-32-5)

Guidance literature:

With bovine β-(1 ->; -galactosyltransferase; magnesium chloride; alkaline phosphatase; benzenesulfonamide; In various solvent(s); at 37 ℃; for 48h; pH=7.0;

DOI:10.1016/j.carres.2004.03.015

Reference yield: 68.0%

glucose 1-phosphate (59-56-3,2240-08-6,2255-14-3,2520-52-7,6799-01-5,10456-01-6,14048-34-1,15978-07-1,19993-19-2,20299-62-1,40591-51-3,62057-78-7,77280-79-6,78341-19-2,27251-84-9,63779-58-8,262856-84-8) + N-[(2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-3-yl]-acetamide (37067-30-4) → 4-methylumbelliferyl β-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside (73448-32-5)

Guidance literature:

With E_. coli K-12 Glc-1-P uridylyltransferase; E_. coli UDP-galactose-4-epimerase; Neisseria meningitidis β1-4-galactosyltransferase encoded by lgtB gene; Pasteurella multocida inorganic pyrophosphatase; uridine 5’-(hydrogen triphosphate); magnesium chloride; at 37 ℃; pH=7.5; regioselective reaction; aq. buffer; Enzymatic reaction;

DOI:10.1039/c0cc01381a

upstream raw materials:

N-[(2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-3-yl]-acetamide

uridine-5'-diphosphoglucose

uridine 5'-diphospho-D-galactose

4-methylumbelliferyl β-D-glucopyranoside