2-Thiophenehexanoic acid, 5-[[5-(phenylmethyl)-2-thienyl]methyl]-

Base Information

• Chemical Name: 2-Thiophenehexanoic acid, 5-[[5-(phenylmethyl)-2-thienyl]methyl]-
• CAS No.: 106181-20-8
• Molecular Formula: C₂₂H₂₄O₂S₂
• Molecular Weight: 384.563
• Mol file: 106181-20-8.mol

Synonyms:

Chemical Property of 2-Thiophenehexanoic acid, 5-[[5-(phenylmethyl)-2-thienyl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenehexanoic acid, 5-[[5-(phenylmethyl)-2-thienyl]methyl]-

There total 3 articles about 2-Thiophenehexanoic acid, 5-[[5-(phenylmethyl)-2-thienyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2'-dithienylmethane (4341-34-8) → 6-(5-(5-Benzyl-2-thenyl)-2-thienyl)hexanoic Acid (106181-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) BuLi / 1) Ether, 0 deg C, 30 min; 2) RT, 15 h then reflux for 9 h

2: 1) SnCl₄, 2) 10percent ethanolic KOH / 1) benzene, 0 deg C, 1 h then 20 deg C, 2 h; 2) reflux, 3 h

3: 1) hydrazine hydrate, 2) KOH / 1) diethylene glycol, 120 deg C, 0.5 h; 2) 195 deg C, 2 h

With potassium hydroxide; n-butyllithium; tin(IV) chloride; hydrazine hydrate;

Reference yield:

2-Benzyl-5-thenylthiophene (106181-18-4) → 6-(5-(5-Benzyl-2-thenyl)-2-thienyl)hexanoic Acid (106181-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) SnCl₄, 2) 10percent ethanolic KOH / 1) benzene, 0 deg C, 1 h then 20 deg C, 2 h; 2) reflux, 3 h

2: 1) hydrazine hydrate, 2) KOH / 1) diethylene glycol, 120 deg C, 0.5 h; 2) 195 deg C, 2 h

With potassium hydroxide; tin(IV) chloride; hydrazine hydrate;

Reference yield:

benzyl chloride (100-44-7) → 6-(5-(5-Benzyl-2-thenyl)-2-thienyl)hexanoic Acid (106181-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) BuLi / 1) Ether, 0 deg C, 30 min; 2) RT, 15 h then reflux for 9 h

2: 1) SnCl₄, 2) 10percent ethanolic KOH / 1) benzene, 0 deg C, 1 h then 20 deg C, 2 h; 2) reflux, 3 h

3: 1) hydrazine hydrate, 2) KOH / 1) diethylene glycol, 120 deg C, 0.5 h; 2) 195 deg C, 2 h

With potassium hydroxide; n-butyllithium; tin(IV) chloride; hydrazine hydrate;

upstream raw materials:

2,2'-dithienylmethane

2-Benzyl-5-thenylthiophene

benzyl chloride

Downstream raw materials:

16-phenyl-hexadecanoic acid

16-phenylhexadecanoic acid methyl ester

Refernces