Technology Process of (S)-methyl 1,3-dibenzyl-5-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylate
There total 9 articles about (S)-methyl 1,3-dibenzyl-5-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran; methanol;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jo200424q
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: caesium carbonate / methanol; water / pH 7
1.2: 3 h / 60 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 4 h / -78 °C / Inert atmosphere
2.2: 2.33 h / -78 - 20 °C / Inert atmosphere
3.1: magnesium sulfate; toluene-4-sulfonic acid / acetonitrile / 15 h / 50 °C / Inert atmosphere
4.1: 2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate / tetrahydrofuran; dichloromethane / 0 °C
4.2: 15 h / 0 - 20 °C / Inert atmosphere
5.1: piperidine / dichloromethane / 0.17 h
6.1: trifluoroacetic acid / 1,2-dichloro-ethane / 3 h / 70 °C / Microwave irradiation
7.1: tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere
With
piperidine; 2,4,6-trimethyl-pyridine; oxalyl dichloride; bis(trichloromethyl) carbonate; magnesium sulfate; caesium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;
6.1: Pictet-Spengler cyclization;
DOI:10.1021/jo200424q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: magnesium sulfate; toluene-4-sulfonic acid / acetonitrile / 15 h / 50 °C / Inert atmosphere
2.1: 2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate / tetrahydrofuran; dichloromethane / 0 °C
2.2: 15 h / 0 - 20 °C / Inert atmosphere
3.1: piperidine / dichloromethane / 0.17 h
4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 3 h / 70 °C / Microwave irradiation
5.1: tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere
With
piperidine; 2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate; magnesium sulfate; toluene-4-sulfonic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
4.1: Pictet-Spengler cyclization;
DOI:10.1021/jo200424q