N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid

Base Information

• Chemical Name: N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid
• CAS No.: 82870-62-0
• Molecular Formula: C₃₀H₃₆N₈O₁₁
• Molecular Weight: 684.663
• Mol file: 82870-62-0.mol

Synonyms:

Chemical Property of N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid

There total 14 articles about N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate (92008-00-9,92008-01-0,107796-08-7) → N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid (82870-62-0,92007-98-2,92007-99-3)

Guidance literature:

With alkaline phosphatase (E_.coli); at 37 ℃; for 1h; Tris-HCl (pH 9.0);

DOI:10.1021/jm00378a031

Reference yield: 55.0%

diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(3',5'-diacetyl-2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate (82855-86-5,92007-94-8,92007-95-9) → N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid (82870-62-0,92007-98-2,92007-99-3)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1021/jm00378a031

Reference yield: 55.0%

2-[4-({5-[1-((2R,4S,5R)-4-Acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl]-2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[3,2-d]pyrimidin-6-ylmethyl}-amino)-benzoylamino]-pentanedioic acid diethyl ester (82855-86-5,92007-94-8,92007-95-9) → N-<4-<<(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-(2'-deoxyuridin-5-yl)methylpyrido<3,2-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid (82870-62-0,92007-98-2,92007-99-3)

Guidance literature:

With sodium hydroxide; In ethanol; Ambient temperature;

DOI:10.1016/S0040-4039(00)87125-7

upstream raw materials:

2-[4-({5-[1-((2R,4S,5R)-4-Acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl]-2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[3,2-d]pyrimidin-6-ylmethyl}-amino)-benzoylamino]-pentanedioic acid diethyl ester

diethyl 5,6,7,8-tetrahydro-8-deazafolate

diethyl N¹⁰-nitroso-8-deazafolate

diethyl 8-deazafolate