C₂₁H₂₃FN₄O₄

Base Information

• Chemical Name: C₂₁H₂₃FN₄O₄
• CAS No.: 1309559-57-6
• Molecular Formula: C₂₁H₂₃FN₄O₄
• Molecular Weight: 414.436
• Mol file: 1309559-57-6.mol

Synonyms:

Chemical Property of C₂₁H₂₃FN₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₃FN₄O₄

There total 16 articles about C₂₁H₂₃FN₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-benzyloxy-N-(4-fluorobenzyl)-1-isopropyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro-1H-imidazo[1,2-d]pyrido[1,2-a]-pyrazine-8-carboxamide (1421314-72-8) → C21H23FN4O4 (1309559-57-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jm301550c

Reference yield:

5-benzyloxy-N-(4-fluorobenzyl)-6-formyl-4-oxo-1,4-dihydropyridine-3-carboxamide (1421314-67-1,906657-94-1) → C21H23FN4O4 (1309559-57-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium chlorite; aminosulfonic acid / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere; Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 °C / Inert atmosphere

4.1: potassium osmate(VI) dihydrate; sodium periodate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

5.1: acetic acid / dichloromethane / 0.5 h / 140 °C / Inert atmosphere

6.1: hydrogen; palladium 10% on activated carbon / methanol; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With potassium osmate(VI) dihydrate; sodium chlorite; sodium periodate; palladium 10% on activated carbon; aminosulfonic acid; hydrogen; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm301550c

Reference yield:

3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid (906657-95-2,906658-58-0) → C21H23FN4O4 (1309559-57-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

1.2: 1.5 h / Inert atmosphere; Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 °C / Inert atmosphere

3.1: potassium osmate(VI) dihydrate; sodium periodate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

4.1: acetic acid / dichloromethane / 0.5 h / 140 °C / Inert atmosphere

5.1: hydrogen; palladium 10% on activated carbon / methanol; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With potassium osmate(VI) dihydrate; sodium periodate; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm301550c

upstream raw materials:

5-benzyloxy-N-(4-fluorobenzyl)-6-formyl-4-oxo-1,4-dihydropyridine-3-carboxamide

3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

methyl 3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate

methyl 1-allyl-3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate