His-D-Trp-Ala-aza-(ethyl dimethylphosphoryl)Gly-D-Phe-Lys-NH₂

Base Information

• Chemical Name: His-D-Trp-Ala-aza-(ethyl dimethylphosphoryl)Gly-D-Phe-Lys-NH₂
• CAS No.: 1320358-93-7
• Molecular Formula: C₄₀H₅₇N₁₂O₉P
• Molecular Weight: 880.941
• Mol file: 1320358-93-7.mol

Synonyms:

Chemical Property of His-D-Trp-Ala-aza-(ethyl dimethylphosphoryl)Gly-D-Phe-Lys-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of His-D-Trp-Ala-aza-(ethyl dimethylphosphoryl)Gly-D-Phe-Lys-NH₂

There total 1 articles about His-D-Trp-Ala-aza-(ethyl dimethylphosphoryl)Gly-D-Phe-Lys-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethylvinylphosphonate (4645-32-3) + C14H11N3O4 (1178561-46-0) + D-Phe-Lys(ε-Boc)-Rink-amide resin + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-His(Trt)-OH (109425-51-6) + 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan (163619-04-3) → His-D-Trp-Ala-aza-(ethyl dimethylphosphoryl)Gly-D-Phe-Lys-NH2 (1320358-93-7)

Guidance literature:

C₁₄H₁₁N₃O₄; D-Phe-Lys(ε-Boc)-Rink-amide resin; at 20 ℃; for 16h; Automated shaker; solid phase reaction;

dimethylvinylphosphonate; With tert-butylimino-tri(pyrrolidino)phosphorane; In tetrahydrofuran; at 20 ℃; for 24h; solid phase reaction;

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-His(Trt)-OH; 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan; Further stages;

DOI:10.1021/ja203007u

upstream raw materials:

dimethylvinylphosphonate

C₁₄H₁₁N₃O₄

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-His(Trt)-OH