1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene

Base Information

• Chemical Name: 1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene
• CAS No.: 98733-08-5
• Molecular Formula: C₁₁H₁₆O₃S
• Molecular Weight: 228.312

Synonyms:

Chemical Property of 1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene

There total 2 articles about 1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-bromo-2,2-dimethoxyethane (7252-83-7) + 3-methoxybenzenethiol (15570-12-4) → 1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene (98733-08-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

1-bromo-2,2-dimethoxyethane (7252-83-7) → 1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene (98733-08-5)

Guidance literature:

With ethanol; sodium iodide;

Reference yield:

1-<(2,2-dimethoxyethyl)thio>-3-methoxybenzene (98733-08-5) → (2R)-2-(4-fluorophenyl)-N-(4-{2-[(6-methoxy-1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)propanamide

Guidance literature:

Multi-step reaction with 8 steps

1: phosphoric acid / chlorobenzene / 1 h / 80 °C

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 2 h / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / dichloromethane; ethanol / 16 h / 20 °C

4: lithium aluminium tetrahydride / diethyl ether / 4 h / Reflux

5: bromine / chloroform / 1 h / 0 °C

6: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

7: potassium phosphate monohydrate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; XPhos / toluene; 1-methyl-pyrrolidin-2-one / 1 h / Inert atmosphere; Reflux

8: potassium phosphate monohydrate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; 1-methyl-pyrrolidin-2-one / 1 h / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; potassium phosphate monohydrate; phosphoric acid; palladium 10% on activated carbon; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; hydrogen; bromine; 3-chloro-benzenecarboperoxoic acid; XPhos; In 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; dichloromethane; chloroform; chlorobenzene; toluene;

upstream raw materials:

1-bromo-2,2-dimethoxyethane

3-methoxybenzenethiol

Downstream raw materials:

6-methoxy-benzo[b]thiophene

4-methoxybenzo[b]thiophene

6-methoxybenzothiophene-1,1-dioxide

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