2-(3-chlorophenyl)-4,4,4-trifluorobutanenitrile

Base Information

• Chemical Name: 2-(3-chlorophenyl)-4,4,4-trifluorobutanenitrile
• CAS No.: 1512840-47-9
• Molecular Formula: C₁₀H₇ClF₃N
• Molecular Weight: 233.62
• Mol file: 1512840-47-9.mol

Synonyms:

Chemical Property of 2-(3-chlorophenyl)-4,4,4-trifluorobutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-chlorophenyl)-4,4,4-trifluorobutanenitrile

There total 2 articles about 2-(3-chlorophenyl)-4,4,4-trifluorobutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Togni's reagent II (887144-94-7) + trimethylsilyl cyanide (7677-24-9) + 3-Chlorostyrene (2039-85-2,26100-04-9) → 2-(3-chlorophenyl)-4,4,4-trifluorobutanenitrile (1512840-47-9)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dimethyl sulfoxide; at 60 ℃; for 0.5h; Mechanism; Inert atmosphere;

DOI:10.1021/ol403263c

Reference yield: 46.0%

trimethylsilyl cyanide (7677-24-9) + 3-Chlorostyrene (2039-85-2,26100-04-9) + 4-dimethylamino-1-(trifluoromethyl)-sulfonylpyridin-1-ium trifluoromethanesulfonate → 2-(3-chlorophenyl)-4,4,4-trifluorobutanenitrile (1512840-47-9)

Guidance literature:

With copper(I) oxide; tris[2-phenylpyridinato-C₂,N]iridium(III); In chloroform; at 35 ℃; for 60h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.1c02146

upstream raw materials:

Togni's reagent II

trimethylsilyl cyanide

3-Chlorostyrene