4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline

Base Information

Chemical Name:4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline
CAS No.:882535-01-5
Molecular Formula:C₁₄H₁₃ClFNO
Molecular Weight:265.715
Hs Code.:
DSSTox Substance ID:DTXSID00469512
Wikidata:Q82297274

Synonyms:4-(3-CHLORO-2-FLUOROBENZYL)-3-METHOXYANILINE;882535-01-5;DTXSID00469512;SB81685;4-[(3-Chloro-2-fluorophenyl)methyl]-3-methoxyaniline

Suppliers and Price of 4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline 97%
1g
$ 550.00

Alichem
4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline
1g
$ 620.10

Total 5 raw suppliers

Chemical Property of 4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:265.0669699
Heavy Atom Count:18
Complexity:266

Purity/Quality:

99% ^*data from raw suppliers

4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)N)CC2=C(C(=CC=C2)Cl)F

Technology Process of 4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline

There total 3 articles about 4-(3-Chloro-2-fluorobenzyl)-3-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₁ClFNO₃

: 882535-01-5
4-(3-chloro-2-fluoro-benzyl)-3-methoxy-phenylamine

Guidance literature:: With acetic acid; zinc;
DOI:10.1021/jm0600139

Reference yield:

: 869893-91-4
3-chloro-2-fluorobenzyl zinc bromide

: 882535-01-5
4-(3-chloro-2-fluoro-benzyl)-3-methoxy-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: PdCl₂(Ph₃P)2 / tetrahydrofuran / Heating

2: Zn; AcOH

With bis-triphenylphosphine-palladium(II) chloride; acetic acid; zinc; In tetrahydrofuran; 1: Negishi coupling;
DOI:10.1021/jm0600139

Reference yield:

: 5458-84-4
2-iodo-5-nitroanisole

: 882535-01-5
4-(3-chloro-2-fluoro-benzyl)-3-methoxy-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: PdCl₂(Ph₃P)2 / tetrahydrofuran / Heating

2: Zn; AcOH

With bis-triphenylphosphine-palladium(II) chloride; acetic acid; zinc; In tetrahydrofuran; 1: Negishi coupling;
DOI:10.1021/jm0600139